Browsing by Author "Sureshkannan, S."
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OtherItem Open Access Clinical Management Of Infectious Tracheobronchitis in a Dog(TANUVAS, Chennai, 2014-07) Anitha, M.; Balagangatharathilagar, M.; Sureshkannan, S.; TANUVASInfectious tracheobronchitis is a contagious respiratory-disease of dog characterized by coughing. It is a mixed infection of bacteria and virus. An one year old male Labrador retriever dog weighing 28kg was brought to the Small Animal Medicine Unit of Madras Veterinary College Teaching Hospital on 06-01-2014 with the complaint of nasal discharge.ThesisItem Open Access COMPARATIVE EVALUATION OF DIAGNOSTIC ASSAYS IN ESTABLISHING H STATUS OF CHRONIC BACTERIAL ZOONOSES(TANUVAS, Chennai, 2015) Prabu, K.; TANUVAS; Gunaseelan, L.; Porteen, K.; Sureshkannan, S.This study Was designed to conduct a cross sectional study for identifying current status of chronic bacterial zoonotic pathogens in dairy cows using conventional and molecular assays and to assess the possible impact on human and animal health. Besides, an attempt is also made to develop a multiplex PCR assay for simultaneous detection of Mycobacterium bovis, Mycobacterium avium subsp. paratuberculosis (MAP) and Brucella abortus in appropriate samples. Risk factors assessment for zoonotic brucellosis and zoonotic tuberculosis in humans Was undertaken through qucstionnaíre responses from the study area to understand the impact on human and animal health.ArticleItem Open Access A Computational Approach to use the Active Compounds in Rosemary (Rosmarinusofficinalis), Responsible for its Anti-Inflammatory Properties, as Potential Ligands in Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)(2014-06) Hari, Archana; Kumarasamy, P.; Sujatha, P.L.; Sureshkannan, S.; Priya, Sankar; TANUVASRosemary is a woody, perennial herb. The herb is known to induce relaxation of the bronchial smooth muscle and intestinal smooth muscle along with reduction in leukotrienes and increased PGE2 production, inhibition of lipid peroxidation, and inhibition of the complement. It is particularly known to have anti-oxidative and anti-inflammatory properties. Inflammatory abnormalities are a large group of disorders that underlie a variety of human diseases. The immune system is often involved with inflammatory disorders, demonstrated in both allergic reactions and some myopathies, with many immune system disorders resulting in abnormal inflammation. The following docking study was performed on the active ingredients in Rosemary that give the herb its anti-inflammatory property. The dock scores were analysed and the best active ingredient-target interactions identified.ThesisItem Open Access CURRENT STATUS OF URBAN LEPTOSPIROSIS IN ANIMAL POPULATION AND ITS PUBLIC HEALTH SIGNIFICANCE.(TANUVAS, Chennai, 2015) Bojiraj, M.; TANUVAS; Porteen, K.; Gunaseelan, L.; Sureshkannan, S.A study was conducted to identify the current status of urban leptospirosis in animal and human population covering different locations in Tamil Nadu by antigen detection method (Dark field microscopy and Polymerase Chain Reaction) and antibody detection (microscopic agglutination test and a developed in house i-ELISA). A total of 931 samples comprising of 118 Canine (serum- 108 and urine -10), 161 bovine (serum- 102, urine- 49, milk-3 and aborted contents-7), 156 equine (serum-152 and urine-4), 153 rodent (serum-60, urine-33 and kidney tissue-60), 177 swine serum and 166 human serum were collected from different locations in Tamil Nadu. All samples were collected from animals/human of unknown disease status.ArticleItem Open Access Designing of Antiviral Sirna for Targeting HIV-1 Subtype C in India(2014-10) Samantha, E. Aashmi; Dhanapalan, P.; Kumarasamy, P.; Sujatha, P.L.; Devendran, P.; Sureshkannan, S.; TANUVASAcquired Immunodeficiency Syndrome (AIDS) is one of the top deadly diseases in the world. The recent studies confirm that neither behavioral therapies nor current antiretroviral drugs are likely to cure HIV infection completely. RNA interference (RNAi) has raised the possibility of developing a new generation of strategies that can prevent HIV-1 replication. Since HIV has high mutation rate, RNAican be made effective only by targeting highly conserved coding regions with optimal stable siRNAs. This study was mainly focused on the identification of highly conserved target sites and designing of stable antiviral siRNAs against HIV-1 subtype C in India. Here, the mutations in HIV-1 subtype C in India were studied using the tool HIVseq. The evolutionary pathway of HIV-1 subtype C in India was inferred through phylogenetic analysis using MEGA4 in the present study. Based on the mutational and phylogenetic studies, the highly conserved target sites were identified using BioEdit. Stable, optimal siRNAs were designed against these conserved target sites using siRNA selection server at Whitehead Institute. siRNAs designed against these conserved target sites were anticipated to resist viral mutational escape and off-target gene silencing. These optimal siRNAs would increase the durability of RNAi against HIV-1 subtype C.ArticleItem Open Access Emerging Zoonotic Diseases - A Potential Risk to Human and Animal Health(TANUVAS, Chennai, 2018-09) Sureshkannan, S.; Rajagunalan, S.; TANUVASThe history of infectious diseases occurrence in human and animal population is very well scripted in epics and olden literatures. The Zoonotic diseases transmitted between human and animals is not a new phenomenon, but the depth of knowledge on common diseases of animals and human beings might have been lesser than the modern understanding but evidence depicts some of the diseases shared between human and animals were found in 3000-year-old Egyptian mummies.ArticleItem Open Access Evaluation of Antitumor Potentials of Herbal Based Natural Products in Experimentally Induced Carcinogenesis In Silico and In Vitro(2016) Preetha, S.P.; Punniamurthy, N.; Balachandran, C.; Cecilia, J.; Mangalagowri, A.; Sureshkannan, S.; Sujatha, P.L.; TANUVASCancer has emerged as one of the most dreaded diseases of the 20th century, spreading further with continuance and increasing incidence in 21stcentury. Though chemoprevention has evolved as a promising and valuable strategy to inhibit, suppress or control the incidence of carcinogenesis, it is essential to explore the chemotherapeutic agents in experimental models before embarking on clinical trials. Experimental tumours have great importance for the purposes of modelling and Ehrlich Ascites Carcinoma (EAC) is one of the commonest since it is an undifferentiated carcinoma with rapid proliferation, high transplantable capability and bears similarities to human tumours. Natural products play a pivotal role in cancer therapy with substantial numbers of anticancer agents being natural or natural derived products with negligible side effects. The use of herbal based natural products may present an affordable and sustainable alternative to synthetic medicines. Acalyphaindica Linn. andTinosporacordifolia are used in Traditional System of Medicine and ethnoveterinary practices with multiple pharmacological activities. Keeping in view the importance and advantages of combination chemotherapy using herbal based natural products on the tumour cells, this study was attempted to explore the influence of combined extracts of Acalyphaindica and Tinosporacordifolia in experimentally induced carcinogenesis invitro. The utility and impact of herbal based natural products, the combined extracts of AcalyphaindicaandTinosporacordifolia in cancer chemotherapy, was tested on EAC cells. The Antitumor efficacy of the herbal based natural products was evaluated with relevant carcinogenesis indicators in Ethno Veterinary Herbal Research and Training Unit for Livestock Health Care, Thanjavur. The Combined extracts of Acalyphaindica and Tinosporacordifoliawas found to have potential anti cancer activity from the in silico and in vitro studies.ThesisItem Open Access IN SILICO ANALYSIS OF ACTIVE PRINCIPLES PRESENT IN GYMNEMA SYLVESTRE AGAINST INSULIN RECEPTOR ON ANTI - DIABETIC EFFECT IN TYPE I AND TYPE II DIABETES(2013) Premchand, S.; Kumarasamy, P.; Sujatha, P.L.; Sureshkannan, S.; TANUVASDiabetes is a metabolic disease characterized by hyperglycemia resulting from defects in insulin secretion and its action. Diabetes can be categorized into three types namely type l diabetes, type ll diabetes and gestational diabetes. The chronic hyperglycemia oi‘ diabetes is associated with long-term damage, dysfunction and failure of various organs mainly the eyes, kidneys, nerves, heart and blood vessels. Generally insulin is used in the treatment of diabetes.OtherItem Open Access In-vitro Lytic Efficacy of Staphylococcus Phage Crude Lysin CL1 and CL3 Against Staphylococcus Isolates from Mastitis Cases(TANUVAS, Chennai, 2012-09) Sureshkannan, S.; Mayankrawat; Anilkumarmishra; Arunkumar, S.; TANUVASThesisItem Open Access Insilico Analysis of Binding Capacity of Flavanolto Obesity Receptor Molecule by Computational Approach of Small Molecule Protein Docking Method(TANUVAS, Chennai, 2013) Sumathi, S.; Sujatha, P.L.; Sureshkannan, S.; TANUVASOtherItem Open Access Insilico Screening and Evaluation of Herbal Bio-active Principles Against "3DPOL" (RNA Polymerase Enzyme) of Foot and Mouth Diseases Virus(TANUVAS, Chennai, 2012-09) Kavitha; Dhanapalan, P.; Kumarasamy, P.; Sureshkannan, S.; Sujatha, P.L.; TANUVASArticleItem Open Access Isolation and Characterization of Vibrio spp. from Sea Food And Environmental Samples in and around Chennai City(TANUVAS, Chennai, 2021-01) Deepak, S.J.; Porteen, K.; Elango, A.; Senthilkumar, T.M.A.; Babu, R. Narendra; Sureshkannan, S.; TANUVASVibrio is a major sea food pathogen which needs to be monitored regularly for devising appropriate control strategy to ensure food safety among sea food consumers and handlers. The present study aims to ascertain the occurrence of Vibrio spp. in seafood viz fishes, prawn/shrimps, crabs and water samples collected from various fish markets in and around Chennai city, Tamil Nadu, India. A total of 175 samples were screened, of which 106 (60.57%) samples were found positive by PCR targeting the 16s rRNA of Vibrio genus and all the positive isolates were subjected to toxR gene identification by Multiplex PCR for species level identification. At the species level 28(26.41%) were positive for Vibrio parahemolyticus (Vp), 6 (5.67%) positive for Vibrio Cholerae (Vc), 2 (1.89%) positive for Vibrio vulnificus (Vv). The presence of mixed vibrio species were also observed of which 56 samples (43.40%) revealed the presence of Vp and Vc, 7 (6.60%) with Vp and Vv, 3 (2.84%) with Vv and Vc and 14 samples with (13.20%) Vp, Vv and Vv. The present study identified the presence along with mixed Vibrio spp. in most of the samples tested from the study area.ThesisItem Open Access PREVALENCE OF Listeria monocytogenes IN INDIAN TRADITIONAL MILK PRODUCTS(TANUVAS, Chennai, 2015) Suriyapriya, S.; Selvan, P.; Sureshkannan, S.; Porteen, K.; TANUVASA study to assess the prevalence of L. monocytogenes in Indian traditional milk products was conducted. Among the five major categories of traditional dairy products viz., Fat rich, Heat and acid coagulated, Heat desiccated, Fermented products and Dairy puddings & desserts, one dairy product in each category that has been preferred by most consumers was identified through a survey conducted at Chennai, Tamilnadu and thereby Ghee, Rasagolla, Gulahjamun, Curd and Payasam were chosen.ArticleItem Open Access Prevalence of Listeria spp. in Traditional Indian Dairy Products from Chennai Metropolis, Tamil Nadu(2016) Suriyapriya, S.; Selvan, P.; Porteen, K.; Sureshkannan, S.; TANUVASThe present study was conducted between September, 2014 and June, 2015 to assess the prevalence of Listeria monocytogenes in Traditional Indian Dairy Products from Chennai, Tamil Nadu. Samples of Ghee, Rasagolla, Gulabjamun, Curd and Payasam were screened for the presence of L. monocytogenes using conventional culture method and validated by PCR. Among the 150 samples screened, 50 isolates from different dairy products (22 gulabjamun, 22 rasagolla and 06 curd samples) were presumptively identified as Listeria spp.ArticleItem Open Access Seroprevalence of Leptospirosis in Animals and Its Public Health Significance(2017-11) Bojiraj, M.; Porteen, K.; Gunaseelan, L.; Sureshkannan, S.; TANUVASA study was conducted to identify the status of seroprevalence of leptospirosis in animal population by Microscopic Agglutination Test (antibody detection) covering different locations in Tamil Nadu, India. A total of 447 sera samples were collected with unknown disease status from different animal species viz., 108 canine, 102 bovine, 177 swine and 60 rodents. 47.2 (51/108) per cent of canine sera, 41.1 (42/102) per cent bovine sera, 15.8 (28/177) per cent swine sera and 40 (24/60) per cent rodent sera were positive for leptospirosis by Microscopic Agglutination Test. Most predominant serovars are Australis and Autumnalis in all species found in this study. Seroprevalence of new serovars other than vaccinal serovars indicates that these serovars may be included in vaccines preparation for prevention of leptospirosis outbreaks in animal and human population.OtherItem Open Access Target Validation of VP1 & VP2 Antigenic Protein of Human & Canine Parvovirus with Antiviral Herbs : A Bioinformatics Approach(TANUVAS, Chennai, 2012-09) Devipriya, P.; Dhanapalan, P.; Kumarasamy, P.; Sureshkannan, S.; Sujatha, P.L.; TANUVASThesisItem Open Access VIRTUAL SCREENING OF PLANT TARGETING LIPOPOLYSACCHARIDES AND PATHWAY IN PATHOGENIC LEPTOSPIRA SEROVARS(TANUVAS, Chennai, 2015) Sumathi, P.; Sureshkannan, S.; Sujatha, P.L.; Kumarasamy, P.; TANUVASHeptospirosis an important zoonotic disease globally affects world population. on molecular and intracellular mechanism of pathogenesis and biosynthesis pathway revealed new targets for the development of novel drugs using computational tools.ArticleItem Open Access ஆடு வளர்ப்போருக்கான கைபேசி செயலி - ஒரு ஆய்வு(Naam Thamizhar Pathippagam, Chennai, 2019-02) Senthilkumar, S.; Manivannan, C.; Sureshkannan, S.; TANUVASதற்பொழுது அனைத்து துறையிலும் கணினி முறைகள் கையாளப்பட்டு வருவதால், வேளாண்பெருமக்களும் அதிகளவு ஆன்ராய்டு கைபேசிகளை பயன்படுத்துகின்றனர் என்பதால், திருநெல்வேலி மாவட்டத்தில் ஆடு வளர்ப்பவர்களை மேம்படுத்துவதற்கான கைபேசி செயலியை உருவாக்கும் திட்டம் நடத்தப்பட்டது. இத்திட்டத்தின் ஒரு நோக்கமாக ஆடு வளர்ப்பவர்களின் தகவல் தேவைகள் ஆராயப்பட்டு ஆடு வளாப்பவர்களின் தகவல் தேவைகளின் சராசரி மதிப்பெண்கள் கணக்கிடப்பட்டுள்ளது.