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Anand Agricultural University, Anand

Anand Agricultural University (AAU) was established in 2004 at Anand with the support of the Government of Gujarat, Act No.(Guj 5 of 2004) dated April 29, 2004. Caved out of the erstwhile Gujarat Agricultural University (GAU), the dream institution of Sardar Vallabhbhai Patel and Dr. K. M. Munshi, the AAU was set up to provide support to the farming community in three facets namely education, research and extension activities in Agriculture, Horticulture Engineering, product Processing and Home Science. At present there seven Colleges, seventeen Research Centers and six Extension Education Institute working in nine districts of Gujarat namely Ahmedabad, Anand, Dahod, Kheda, Panchmahal, Vadodara, Mahisagar, Botad and Chhotaudepur AAU's activities have expanded to span newer commodity sectors such as soil health card, bio-diesel, medicinal plants apart from the mandatory ones like rice, maize, tobacco, vegetable crops, fruit crops, forage crops, animal breeding, nutrition and dairy products etc. the core of AAU's operating philosophy however, continues to create the partnership between the rural people and committed academic as the basic for sustainable rural development. In pursuing its various programmes AAU's overall mission is to promote sustainable growth and economic independence in rural society. AAU aims to do this through education, research and extension education. Thus, AAU works towards the empowerment of the farmers.

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2008 - 20097
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Subject: Veterinary Pharmacology × End date: 2009 × Start date: 2008 ×
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Now showing 1 - 7 of 7
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    ThesisItemOpen Access
    PHARMACOKINETICS AND SAFETY STUDY OF LEVOFLOXACIN IN LAYER BIRDS
    (AAU, Anand, 2008) PATEL, JATINKUMAR HARGOVINDDAS; Thaker, A. M.
    Levofloxacin is the active L - isomer of the racemate ofloxacin, a fluorinated quinolone has broad-spectrum activity and good antibacterial activity at low plasma/tissue concentration. The present study was designed to investigate pharmacokinetics of levofloxacin following single dose intravenous and oral administration at the dose rate of 10 mg/kg of body weight and to evaluate safety after repeated administration (10 mg/kg) of levofloxacin at 12 hours interval for 14 days in layer birds. Drug concentration in serum was determined using High Performance Liquid Chromatography (HPLC). Following intravenous administration, the serum drug concentration-time curves were analyzed by non-compartmental approach. Following intravenous administration the therapeutically effective serum concentration of levofloxacm > 0.13 µg/ml was maintamed for up to 12 hours. Based on the serum drug concentrations, various pharmacokinetic parameters like elimination half-life (t1/2β) (3.08 ± 0.05 hours), apparent volume of distribution (Vd(area)) (4.02 ± 0.079 1/kg), volume of distribution of drug at steady-state (Vd(ss)) (3.23 ± 0.055 1/kg), total body clearance (CIB) (15.09 ± 0.21 ml/min/kg), area under serum drug concentration-time curve (AUG) (11.07 ± 0.14 µg.h/ml), area under first moment of curve (AUMC) (39.56 ± 0.89 µg.h2/ml) and mean residence time (MRT) (3.57 ± 0.052 hours) were determined.
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    ThesisItemOpen Access
    PHARMACOKINETICS AND SAFETY STUDY OF LEVOFLOXACIN IN BROILER BIRDS
    (AAU, Anand, 2008) VARIA, RASESHKUMAR DEVABHAI; Thaker, A. M.
    Levofloxacin is the S- enantiomer (L- isomer) of ofloxacin, has broad spectrum of antibacterial activity. The present study was conducted to determine the pharmacokinetics of levofloxacin after single dose intravenous and oral administration at the dose rate of 10 mg/kg body weight in broiler birds. Additionally, tissue concentration (4 doses and 10 doses) and safety of multiple oral doses (28 doses) were evaluated at the same dose rate. Drug concentration in plasma was determined using High Performance Liquid Chromatography (HPLC). Pharmacokinetic parameters were calculated using non-compartmental software. Following intravenous administration the plasma concentration of levofloxacin > 0.15 µg/ml was maintained for up to 12 hours. Based on the plasma drug concentrations, various pharmacokinetic parameters like elimination half-life (t1/2β) (3.178 ± 0.070 hours), apparent volume of distribution Vd(area) (4.044 ± 0.077 1/kg), volvmie of distribution of drug at steady-state Vd(ss) (3.245 ± 0.059 1/kg), total body clearance (CIB) (14.710 ± 0.118 ml/min/kg), area under plasma drug concentration-time curve (AUC) (11.330 + 0.083 µg h/ml), area under first moment of curve (AUMC) (41.730 ± 1.148 µg h2/ml) and mean residence time (MRT) (3.690 + 0.082 hours) were determined.
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    ThesisItemOpen Access
    STUDY ON GENOTOXICITY OF ACEPHATE INDUCED BY REPEATED ORAL ADMINISTRATION IN WISTAR RATS
    (Anand Agricultural University, 2008) JADHAV SANDIP RAMCHANDRA; Dr. S.K. Bhavsar
    Organophosphates are the most frequently used pesticides because of their rapid breakdown into environmentally safe products. Acephate, a water-soluble insecticide, belongs to the phosphoramidothioate group of organophosphate insecticides. It has moderate persistence with residual systemic activity of about 10-15 days. It is being widely used for protection of vegetables and fruits due to its activity against lepidopterans and aphids. As this insecticide is in use as crop protectant, it is likely to cause indirect exposure to animals and humans through contaminated feed, soil and water. Hence the present study was conducted to find out genotoxic potential of acephate.
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    ThesisItemOpen Access
    STUDIES ON PHARMACOKINETICS, BIOAVAILABILITY AND SAFETY OF KETOPROFEN IN KANKREJ CALVES
    (Anand Agricultural University, 2008) BARHATE PARESH VINOD; Dr. A. M. Thaker
    Ketoprofen (KTP) is an aryl propionic acid derivative, a strong non-selective cyclooxygenase inhibitor NSAID. The present study was conducted to determine the pharmacokinetics of ketoprofen after its single dose intravenous and intramuscular administration in six Kankrej calves. The drug was administered at the dose rate of 3.0 mg.kg-1 body weight and assayed in plasma by HPLC analysis. The present study also evaluated safety of ketoprofen (3.0 mg.kg-1) after repeated administration at 24 h interval for 5 days in calves
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    ThesisItemOpen Access
    “PHARMACOKINETICS AND SAFETY STUDY OF LEVOFLOXACIN IN LAYER BIRDS
    (Anand Agricultural University, 2008) PATEL JATINKUMAR HARGOVINDBHAI; Dr. A. M. Thaker
    Levofloxacin is the active L - isomer of the racemate ofloxacin, a fluorinated quinolone has broad-spectrum activity and good antibacterial activity at low plasma/tissue concentration. The present study was designed to investigate pharmacokinetics of levofloxacin following single dose intravenous and oral administration at the dose rate of 10 mg/kg of body weight and to evaluate safety after repeated administration (10 mg/kg) of levofloxacin at 12 hours interval for 14 days in layer birds. Drug concentration in serum was determined using High Performance Liquid Chromatography (HPLC). Following intravenous administration, the serum drug concentration-time curves were analyzed by non-compartmental approach.
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    ThesisItemOpen Access
    EVALUATION OF GENOTOXICITY FOLLOWING REPEATED ORAL ADMINISTRATION OF CYPERMETHRIN IN WISTAR RATS
    (Anand Agricultural University, 2008) MORE AMAR SUNIL; Dr. A. M. Thaker
    Pyrethroids have become the most frequently used pesticides because of more stability in light and good insecticidal activity. Cypermethrin is an insecticide of the synthetic pyrethroid family. Over ninety percent of the cypermethrin, manufactured worldwide, is used to kill insects mainly on cotton and other agricultural crops. It is also used on lettuce and pecans to kill cockroaches (and other indoor pests), in buildings and to kill termites. As this insecticide is in use as a crop protectant, it is likely to cause indirect exposure of animals and humans through contaminated feed, soil and water, leading to some biological alterations. Hence present study was conducted to find out genotoxic potential of cypermethrin.
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    ThesisItemOpen Access
    STUDY OF EFFICACY AND TOXICITY OF ROSUVASTATIN IN NORMAL AND HIGH FATHIGH CHOLESTEROL DIET FED HAMSTERS
    (Anand Agricultural University, Anand, 2009) ANIL KALIDAS GOTHI; Dr. A. M. Thaker
    Rosuvastatin, a new statin is indicated for the treatment of dyslipidemia. The present study was conducted to evaluate the efficacy and toxicity of rosuvastatin in normal and high fat-high cholesterol diet fed (dyslipidemic) hamsters. The study was conducted on 86 male Golden Syrian hamsters. The animals were administered with rosuvastatin at 1, 10, 25, 50 and 100 mg/kg doses in normal diet fed hamsters and at 0.1, 0.3, 0.5, 1 and 1.5 mg/kg doses in high fat high cholesterol diet fed hamsters. The animals were observed throughout the experimental period for any toxic manifestation and daily body weight was recorded to see the effect. At 0, 7th and 14th days of treatment, animals were subjected to blood collection and serum sample were analyzed for different biochemical parameters. At the end of treatment period animals were sacrificed and necropsy was performed, and tissues were collected (heart, liver, kidney and muscle) for histopathological studies