“PHARMACOKINETICS AND SAFETY STUDY OF LEVOFLOXACIN IN LAYER BIRDS
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Date
2008
Authors
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Publisher
Anand Agricultural University
Abstract
Levofloxacin is the active L - isomer of the racemate ofloxacin, a fluorinated
quinolone has broad-spectrum activity and good antibacterial activity at low
plasma/tissue concentration. The present study was designed to investigate
pharmacokinetics of levofloxacin following single dose intravenous and oral
administration at the dose rate of 10 mg/kg of body weight and to evaluate safety after
repeated administration (10 mg/kg) of levofloxacin at 12 hours interval for 14 days in
layer birds. Drug concentration in serum was determined using High Performance
Liquid Chromatography (HPLC). Following intravenous administration, the serum
drug concentration-time curves were analyzed by non-compartmental approach.
Description
Keywords
Veterinary Pharmacology, Study