STUDY OF EFFICACY AND TOXICITY OF ROSUVASTATIN IN NORMAL AND HIGH FATHIGH CHOLESTEROL DIET FED HAMSTERS
Loading...
Date
2009
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Anand Agricultural University, Anand
Abstract
Rosuvastatin, a new statin is indicated for the treatment of dyslipidemia. The
present study was conducted to evaluate the efficacy and toxicity of rosuvastatin in
normal and high fat-high cholesterol diet fed (dyslipidemic) hamsters. The study was
conducted on 86 male Golden Syrian hamsters. The animals were administered with
rosuvastatin at 1, 10, 25, 50 and 100 mg/kg doses in normal diet fed hamsters and at
0.1, 0.3, 0.5, 1 and 1.5 mg/kg doses in high fat high cholesterol diet fed hamsters. The
animals were observed throughout the experimental period for any toxic manifestation
and daily body weight was recorded to see the effect. At 0, 7th and 14th days of
treatment, animals were subjected to blood collection and serum sample were
analyzed for different biochemical parameters. At the end of treatment period animals
were sacrificed and necropsy was performed, and tissues were collected (heart, liver,
kidney and muscle) for histopathological studies
Description
Keywords
Veterinary Pharmacology, Study