PHARMACOKINETICS AND SAFETY STUDY OF LEVOFLOXACIN IN BROILER BIRDS
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Date
2008
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AAU, Anand
Abstract
Levofloxacin is the S- enantiomer (L- isomer) of ofloxacin, has broad spectrum of antibacterial activity. The present study was conducted to determine the pharmacokinetics of levofloxacin after single dose intravenous and oral administration at the dose rate of 10 mg/kg body weight in broiler birds. Additionally, tissue concentration (4 doses and 10 doses) and safety of multiple oral doses (28 doses) were evaluated at the same dose rate. Drug concentration in plasma was determined using High Performance Liquid Chromatography (HPLC). Pharmacokinetic parameters were calculated using non-compartmental software. Following intravenous administration the plasma concentration of levofloxacin > 0.15 µg/ml was maintained for up to 12 hours. Based on the plasma drug concentrations, various pharmacokinetic parameters like elimination half-life (t1/2β) (3.178 ± 0.070 hours), apparent volume of distribution Vd(area) (4.044 ± 0.077 1/kg), volvmie of distribution of drug at steady-state Vd(ss) (3.245 ± 0.059 1/kg), total body clearance (CIB) (14.710 ± 0.118 ml/min/kg), area under plasma drug concentration-time curve (AUC) (11.330 + 0.083 µg h/ml), area under first moment of curve (AUMC) (41.730 ± 1.148 µg h2/ml) and mean residence time (MRT) (3.690 + 0.082 hours) were determined.
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VETERINARY PHARMACOLOGY, A STUDY