Pharmacokinetics of metronidazole in ruminants and its effect on the Haematological and biochemical parameters with special reference to Goats
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Date
1984
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Birsa Agricultural University
Abstract
1.Thesemilogarithmic plot of blood level-time profile obtained in buffalo calves after I/V administration of MNZ 20 mg/kg b.w. showed biphasic decay which indicated" two compartment open model " disposition kinetics of MNZ in consonance with first order kinetics.
2. It has been observed that MNZ given I/V as a single dose 20 mg/g b.w. in buffalo calves produced CB ther above 0.7 ug/ml upto 6 hr post-administration.
3. It has been evidenced that tk (3) of MNZ in buffalo calves was 155.00+10.58 min while the Cl, value was 4.38+0.23 ml//min suggesting rapid elimination of the compound. The V'd value determined was 0.98+0.09 L/ which indicated its penetration into total body water spaces.
4. Evidence has been adduced that the buffalo plasma protein binding of MNZ ranged between 21.54 to 65.35% at plasma drug concentration ranging from 200 to 25 ug/ml.
5.It has been observed that MNZ concentration in buffalo erythrocytes (6.8 x 109/ml) ranged from 10.30 to 22.74ug/ml at a total blood drug concentration ranging between 400 to 50 ug/ml which suggested significant erythrocyte uptake of the compound
Description
Pharmacokinetics of metronidazole in ruminants and its effect on the Haematological and biochemical parameters with special reference to Goats