Pharmacokinetics of metronidazole in ruminants and its effect on the Haematological and biochemical parameters with special reference to Goats

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dc.contributor.advisorYadava, K.P.
dc.contributor.authorMandal, Tapan Kumar
dc.date.accessioned2023-02-28T07:11:18Z
dc.date.available2023-02-28T07:11:18Z
dc.date.issued1984
dc.descriptionPharmacokinetics of metronidazole in ruminants and its effect on the Haematological and biochemical parameters with special reference to Goatsen_US
dc.description.abstract1.Thesemilogarithmic plot of blood level-time profile obtained in buffalo calves after I/V administration of MNZ 20 mg/kg b.w. showed biphasic decay which indicated" two compartment open model " disposition kinetics of MNZ in consonance with first order kinetics. 2. It has been observed that MNZ given I/V as a single dose 20 mg/g b.w. in buffalo calves produced CB ther above 0.7 ug/ml upto 6 hr post-administration. 3. It has been evidenced that tk (3) of MNZ in buffalo calves was 155.00+10.58 min while the Cl, value was 4.38+0.23 ml//min suggesting rapid elimination of the compound. The V'd value determined was 0.98+0.09 L/ which indicated its penetration into total body water spaces. 4. Evidence has been adduced that the buffalo plasma protein binding of MNZ ranged between 21.54 to 65.35% at plasma drug concentration ranging from 200 to 25 ug/ml. 5.It has been observed that MNZ concentration in buffalo erythrocytes (6.8 x 109/ml) ranged from 10.30 to 22.74ug/ml at a total blood drug concentration ranging between 400 to 50 ug/ml which suggested significant erythrocyte uptake of the compounden_US
dc.identifier.urihttps://krishikosh.egranth.ac.in/handle/1/5810194601
dc.keywordsPharmacokinetics of metronidazole in ruminants and its effect on the Haematological and biochemical parameters with special reference to Goatsen_US
dc.language.isoEnglishen_US
dc.pages103en_US
dc.publisherBirsa Agricultural Universityen_US
dc.subVeterinary Pharmacology and Toxicologyen_US
dc.themePharmacokinetics of metronidazole in ruminants and its effect on the Haematological and biochemical parameters with special reference to Goatsen_US
dc.these.typeM.V.Sc.en_US
dc.titlePharmacokinetics of metronidazole in ruminants and its effect on the Haematological and biochemical parameters with special reference to Goatsen_US
dc.typeThesisen_US
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