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Anand Agricultural University, Anand

Anand Agricultural University (AAU) was established in 2004 at Anand with the support of the Government of Gujarat, Act No.(Guj 5 of 2004) dated April 29, 2004. Caved out of the erstwhile Gujarat Agricultural University (GAU), the dream institution of Sardar Vallabhbhai Patel and Dr. K. M. Munshi, the AAU was set up to provide support to the farming community in three facets namely education, research and extension activities in Agriculture, Horticulture Engineering, product Processing and Home Science. At present there seven Colleges, seventeen Research Centers and six Extension Education Institute working in nine districts of Gujarat namely Ahmedabad, Anand, Dahod, Kheda, Panchmahal, Vadodara, Mahisagar, Botad and Chhotaudepur AAU's activities have expanded to span newer commodity sectors such as soil health card, bio-diesel, medicinal plants apart from the mandatory ones like rice, maize, tobacco, vegetable crops, fruit crops, forage crops, animal breeding, nutrition and dairy products etc. the core of AAU's operating philosophy however, continues to create the partnership between the rural people and committed academic as the basic for sustainable rural development. In pursuing its various programmes AAU's overall mission is to promote sustainable growth and economic independence in rural society. AAU aims to do this through education, research and extension education. Thus, AAU works towards the empowerment of the farmers.

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2012 - 20165
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Subject: Veterinary Pharmacology × Start date: 2012 ×
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Now showing 1 - 5 of 5
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    ThesisItemOpen Access
    STUDIES ON ANTIDIABETIC EFFECT OF AQUEOUS AND ALCOHOLIC EXTRACTS OF MORINGA OLEIFERA IN STREPTOZOTOCIN INDUCED DIABETIC RATS
    (AAU, Anand, 2016) KARETHA HETALBEN BHIKHALAL; Dr. A. M. Thaker
    The present study was conducted on sixty six (66) male Albino Wistar rats dividing them in various groups having six rats in each group. Group I served as vehicle control and received 0.5 % solution of sodium bicarbonate in normal saline orally once daily for 28 days. Group II served as diabetic control and received streptozotocin at the dose rate of 60 mg/kg body weight, by dissolving it in 50 mM citric buffer (pH 4.5) solution as a single intraperitoneal injection. Rats of group III, IV, V, VI, VII, VIII and IX also received streptozotocin at the same way. Group III received glibenclamide at dose of 5 mg/kg of body weight (p.o.) once daily after establishment of diabetes for 28 days. Group IV, V and VI received aqueous extract of M. oleifera pods at dose of 100 and 200 and 400 mg/kg respectively (p.o.) once daily respectively while group VII, VIII and IX received alcoholic extract of M. oleifera pods at dose of 100 and 200 and 400 mg/kg (p.o.) respectively once daily after establishment of diabetes for 28 days. Whereas group X and XI were administered with aqueous and alcoholic extracts of M. oleifera pods respectively at dose of 200 mg/kg orally once daily for 28 days. Upon acute oral toxicity testing, aqueous and alcoholic extracts of Moringa oleifera pods were found safe. Phytochemical analysis by GC-MS revealed presence of many compounds in both aqueous and alcoholic extracts of pods. Rats of diabetic “Studies on antidiabetic effect of aqueous and alcoholic extracts of Moringa oleifera in streptozotocin induced diabetic rats” control group were found dull and depressed along with polydipsia, polyphagia and polyuria from first week of experiment. At the end of experiment, there was significant reduction in the body weight gain and increased feed consumption was found in diabetic rats which was significantly reversed with administration of standard drug, aqueous and alcoholic extracts of M. oleifera pods. Administration of aqueous and alcoholic extracts of M. oleifera pods at dose rate of 100, 200 and 400 mg/kg body weight and glibenclamide at 5 mg/kg body weight in diabetic rat for 28 days showed significant (p<0.01) reduction in the elevated level of blood glucose and TLC and significant (p<0.01) increase in the reduced level of Hb, RBCs, PCV, MCV, MCH and MCHC in dose- dependent manner. Daily oral administration of glibenclamide at 5 mg/kg body weight and aqueous and alcoholic extracts of M. oleifera pods at dose rate of 100, 200 and 400 mg/kg body weight in diabetic rats for 28 days produced significant (p<0.01) reduction in the elevated level of SGPT, SGOT, TC, LDH, CK and BUN and significant (p<0.01) increase in the reduced level of liver glycogen, albumin and total protein in dose- dependent manner. Microscopic examination of pancreas revealed destruction, decreased number, dearrangement, diminished size and shape of β cells of islets of langerhans and damaged acinar cells, while histopathological examination of pancreas of both extracts and glibenclamide treated groups revealed restoration in damaged histoarchitecture structure. The hypoglycemic effect of glibenclamide, as a reference drug on reducing blood glucose was more potent and significant as compared to plant extracts (aqueous “Studies on antidiabetic effect of aqueous and alcoholic extracts of Moringa oleifera in streptozotocin induced diabetic rats” and alcoholic extracts of M. oleifera pods) treatment and brought all the hematological and biochemical parameters up to the normal level. Aqueous and alcoholic extracts of M. oleifera pods showed effectiveness in dose- dependent manner. Both aqueous and alcoholic extracts of the M. oleifera pods at the dose rate of 400 mg/kg body weight showed better effect than dose rate of 100 and 200 mg/kg body weight. The antidiabetic activity of aqueous and alcoholic extracts of M. oleifera pods may be due to the presence of phytochemical constituents such as quercetin, flavonoids, phenol, glycoside and alkaloids. Further investigation to define its clinical efficacy would be highly desirable.
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    ThesisItemOpen Access
    SUB-ACUTE TOXICITY STUDY OF PIROXICAM FOLLOWING REPEATED ORAL ADMINISTRATION IN WISTAR RATS”
    (Anand Agricultural University, Anand, 2012) VIHOL KIRANSINH ANDUBHAI; Dr. A. M. Thaker
    The present study was conducted on 8-12 weeks old Wistar rats. Forty eight (24 Male + 24 Female) rats were randomly divided into eight (I, II, III, IV, V, VI, VII and VIII) groups. Each group consists of six animals. Group I served as male control and group V served as female control and received only vehicle till 28 days of dosing period. Group II, III and IV consists of 6 male animals in each group and they received piroxicam at dose of 1, 7 and 15 mg/kg respectively orally till day 28 of dosing period. Similarly group VI, VII and VIII consists of 6 female animals in each and they received piroxicam at dose of 1, 7 and 15 mg/kg respectively orally till day 28 of dosing period. All the animals were monitored throughout
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    ThesisItemOpen Access
    “SUB-ACUTE ORAL TOXICITY STUDY OF ATORVASTATIN ALONE AND IN COMBINATION WITH VERAPAMIL FOLLOWING REPEATED ADMINISTRATION IN HYPERLIPIDEMIC RATS”
    (Anand Agricultural University, Anand, 2012) PATEL JAYESHKUMAR BACHUBHAI; Dr. A. M. Thaker
    Atorvastatin, a second-generation potent inhibitor of 3-Hydroxy 3- Methylglutaryl coenzyme A reductase is indicated for the treatment of dyslipidemia. The present study was conducted to evaluate the toxicity potential of Atorvastatin alone and in combination with Verapamil in hyperlipidemic rats. The study was conducted on 48 male Wistar rats dividing them in various groups having six rats in each group. Group I served as vehicle control and received 1.0 ml of 0.5% sodium bicarbonate solution orally for 28 days of dosing period. Group II served as hyperlipidemic control. Atorvastatin was given orally at dose rate of 0.5, 2.5 and 5.0 mg/kg body weight in poloxamer-407 induced hyperlipidemic rats of group III, IV and V respectively. Poloxamer-407 induced hyperlipidemic rats of group VI, VII and VIII received Atorvastatin at dose rate of 0.5, 2.5 and 5.0 mg/kg body weight respectively and additionally received Verapamil orally at dose rate of 10 mg/kg body weight. Animals were observed daily for clinical signs and mortality
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    ThesisItemOpen Access
    STUDIES ON EFFECT OF TOLFENAMIC ACID AND BIOENHANCER TRIKATU ON PHARMACOKINETICS OF CEFQUINOME AND SAFETY OF SIMULTANEOUS ADMINISTRATION OF CEFQUINOME AND TOLFENAMIC ACID IN PATANWADI SHEEP
    (AAU, Anand, 2014) RANA, MAYANKKUMAR PRABHUBHAI; Dr. A. M. Thaker
    Antibacterials are frequently recommended as an adjunct therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) to treat various bacterial infections and inflammatory conditions in animals. Cefquinome is a fourth-generation cephalosporin, which has been developed solely for veterinary use. It shows potent antibacterial activity against a broad spectrum of bacterial species including those that are resistant to conventional antibacterial drug. Tolfenamic acid (TA) is a new NSAID having antiinflammatory, analgesic and antipyretic properties. In veterinary practice, tolfenamic acid is used clinically as an anti-inflammatory and analgesic agent for the therapy of locomotor diseases in the dog and post-operative pain in cats. Pharmacokinetics of an antibacterial drug may change when administered with anti-inflammatory drug. Despite the potential for clinical use of cefquinome, the data on its pharmacokinetics interaction and safety profile in sheep are not available. Ancient and recent scientific literature cited reference of bioenhancer like trikatu application to increase bioavailability of drug and nutrients. Moreover, it is well known in ruminant animals that oral bioavailability of drug is low as compared to monogastric animals. Looking to this, present study was conceptualized to determine the effect of tolfenamic acid (2 mg/kg body weight) on pharmacokinetics of cefquinome (2 mg/kg body weight) following its intramuscular administration in sheep and safety of daily intramuscular administration of cefquinome (2 mg/kg body weight) in combination with tolfenamic acid (2 mg/kg body weight) for five days in sheep by monitoring hematological and blood biochemical profiles. Moreover, effect of bioenhancer trikatu on pharmacokinetics of cefquinome following intramuscular administration (2 mg/kg body weight) in sheep was evaluated.
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    ThesisItemOpen Access