“SUB-ACUTE ORAL TOXICITY STUDY OF ATORVASTATIN ALONE AND IN COMBINATION WITH VERAPAMIL FOLLOWING REPEATED ADMINISTRATION IN HYPERLIPIDEMIC RATS”
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Date
2012
Authors
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Publisher
Anand Agricultural University, Anand
Abstract
Atorvastatin, a second-generation potent inhibitor of 3-Hydroxy 3-
Methylglutaryl coenzyme A reductase is indicated for the treatment of dyslipidemia.
The present study was conducted to evaluate the toxicity potential of Atorvastatin
alone and in combination with Verapamil in hyperlipidemic rats. The study was
conducted on 48 male Wistar rats dividing them in various groups having six rats in
each group. Group I served as vehicle control and received 1.0 ml of 0.5% sodium
bicarbonate solution orally for 28 days of dosing period. Group II served as
hyperlipidemic control. Atorvastatin was given orally at dose rate of 0.5, 2.5 and 5.0
mg/kg body weight in poloxamer-407 induced hyperlipidemic rats of group III, IV
and V respectively. Poloxamer-407 induced hyperlipidemic rats of group VI, VII and
VIII received Atorvastatin at dose rate of 0.5, 2.5 and 5.0 mg/kg body weight
respectively and additionally received Verapamil orally at dose rate of 10 mg/kg body
weight.
Animals were observed daily for clinical signs and mortality
Description
Keywords
Veterinary Pharmacology, Study