“SUB-ACUTE ORAL TOXICITY STUDY OF ATORVASTATIN ALONE AND IN COMBINATION WITH VERAPAMIL FOLLOWING REPEATED ADMINISTRATION IN HYPERLIPIDEMIC RATS”

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dc.contributor.advisorDr. A. M. Thaker
dc.contributor.authorPATEL JAYESHKUMAR BACHUBHAI
dc.date.accessioned2017-05-20T10:25:18Z
dc.date.available2017-05-20T10:25:18Z
dc.date.issued2012
dc.description.abstractAtorvastatin, a second-generation potent inhibitor of 3-Hydroxy 3- Methylglutaryl coenzyme A reductase is indicated for the treatment of dyslipidemia. The present study was conducted to evaluate the toxicity potential of Atorvastatin alone and in combination with Verapamil in hyperlipidemic rats. The study was conducted on 48 male Wistar rats dividing them in various groups having six rats in each group. Group I served as vehicle control and received 1.0 ml of 0.5% sodium bicarbonate solution orally for 28 days of dosing period. Group II served as hyperlipidemic control. Atorvastatin was given orally at dose rate of 0.5, 2.5 and 5.0 mg/kg body weight in poloxamer-407 induced hyperlipidemic rats of group III, IV and V respectively. Poloxamer-407 induced hyperlipidemic rats of group VI, VII and VIII received Atorvastatin at dose rate of 0.5, 2.5 and 5.0 mg/kg body weight respectively and additionally received Verapamil orally at dose rate of 10 mg/kg body weight. Animals were observed daily for clinical signs and mortalityen_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810011833
dc.keywordsSUB-ACUTE ORAL TOXICITY STUDY, ATORVASTATIN ALONE, VERAPAMIL, HYPERLIPIDEMIC RATS”, RATS”,en_US
dc.language.isoenen_US
dc.publisherAnand Agricultural University, Ananden_US
dc.research.problemSUB-ACUTE ORAL TOXICITY STUDY OF ATORVASTATIN ALONE AND IN COMBINATION WITH VERAPAMIL FOLLOWING REPEATED ADMINISTRATION IN HYPERLIPIDEMIC RATS”en_US
dc.subVeterinary Pharmacologyen_US
dc.subjectVeterinary Pharmacologyen_US
dc.subjectStudyen_US
dc.themeATORVASTATIN ALONEen_US
dc.these.typeM.V.Sc.en_US
dc.title“SUB-ACUTE ORAL TOXICITY STUDY OF ATORVASTATIN ALONE AND IN COMBINATION WITH VERAPAMIL FOLLOWING REPEATED ADMINISTRATION IN HYPERLIPIDEMIC RATS”en_US
dc.typeThesisen_US
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