STUDIES ON EFFECT OF TOLFENAMIC ACID AND BIOENHANCER TRIKATU ON PHARMACOKINETICS OF CEFQUINOME AND SAFETY OF SIMULTANEOUS ADMINISTRATION OF CEFQUINOME AND TOLFENAMIC ACID IN PATANWADI SHEEP
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Date
2014
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Publisher
AAU, Anand
Abstract
Antibacterials are frequently recommended as an adjunct therapy with nonsteroidal
anti-inflammatory drugs (NSAIDs) to treat various bacterial infections and
inflammatory conditions in animals. Cefquinome is a fourth-generation cephalosporin,
which has been developed solely for veterinary use. It shows potent antibacterial activity
against a broad spectrum of bacterial species including those that are resistant to
conventional antibacterial drug. Tolfenamic acid (TA) is a new NSAID having antiinflammatory,
analgesic and antipyretic properties. In veterinary practice, tolfenamic
acid is used clinically as an anti-inflammatory and analgesic agent for the therapy of
locomotor diseases in the dog and post-operative pain in cats. Pharmacokinetics of an
antibacterial drug may change when administered with anti-inflammatory drug. Despite
the potential for clinical use of cefquinome, the data on its pharmacokinetics interaction
and safety profile in sheep are not available. Ancient and recent scientific literature cited
reference of bioenhancer like trikatu application to increase bioavailability of drug and
nutrients. Moreover, it is well known in ruminant animals that oral bioavailability of
drug is low as compared to monogastric animals.
Looking to this, present study was conceptualized to determine the effect of
tolfenamic acid (2 mg/kg body weight) on pharmacokinetics of cefquinome
(2 mg/kg body weight) following its intramuscular administration in sheep and safety of
daily intramuscular administration of cefquinome (2 mg/kg body weight) in combination
with tolfenamic acid (2 mg/kg body weight) for five days in sheep by monitoring
hematological and blood biochemical profiles. Moreover, effect of bioenhancer trikatu
on pharmacokinetics of cefquinome following intramuscular administration (2 mg/kg
body weight) in sheep was evaluated.
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Keywords
veterinary science, pharmacology, study