STUDIES ON EFFECT OF TOLFENAMIC ACID AND BIOENHANCER TRIKATU ON PHARMACOKINETICS OF CEFQUINOME AND SAFETY OF SIMULTANEOUS ADMINISTRATION OF CEFQUINOME AND TOLFENAMIC ACID IN PATANWADI SHEEP

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dc.contributor.advisorDr. A. M. Thaker
dc.contributor.authorRANA, MAYANKKUMAR PRABHUBHAI
dc.date.accessioned2017-03-04T09:23:21Z
dc.date.available2017-03-04T09:23:21Z
dc.date.issued2014
dc.description.abstractAntibacterials are frequently recommended as an adjunct therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) to treat various bacterial infections and inflammatory conditions in animals. Cefquinome is a fourth-generation cephalosporin, which has been developed solely for veterinary use. It shows potent antibacterial activity against a broad spectrum of bacterial species including those that are resistant to conventional antibacterial drug. Tolfenamic acid (TA) is a new NSAID having antiinflammatory, analgesic and antipyretic properties. In veterinary practice, tolfenamic acid is used clinically as an anti-inflammatory and analgesic agent for the therapy of locomotor diseases in the dog and post-operative pain in cats. Pharmacokinetics of an antibacterial drug may change when administered with anti-inflammatory drug. Despite the potential for clinical use of cefquinome, the data on its pharmacokinetics interaction and safety profile in sheep are not available. Ancient and recent scientific literature cited reference of bioenhancer like trikatu application to increase bioavailability of drug and nutrients. Moreover, it is well known in ruminant animals that oral bioavailability of drug is low as compared to monogastric animals. Looking to this, present study was conceptualized to determine the effect of tolfenamic acid (2 mg/kg body weight) on pharmacokinetics of cefquinome (2 mg/kg body weight) following its intramuscular administration in sheep and safety of daily intramuscular administration of cefquinome (2 mg/kg body weight) in combination with tolfenamic acid (2 mg/kg body weight) for five days in sheep by monitoring hematological and blood biochemical profiles. Moreover, effect of bioenhancer trikatu on pharmacokinetics of cefquinome following intramuscular administration (2 mg/kg body weight) in sheep was evaluated.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810003882
dc.keywordsPATANWADI SHEEP, CEFQUINOME, TOLFENAMIC ACID, BIOENHANCER TRIKATU, PHARMACOKINETICS, CEFQUINOMEen_US
dc.language.isoenen_US
dc.publisherAAU, Ananden_US
dc.research.problemSTUDIES ON EFFECT OF TOLFENAMIC ACID AND BIOENHANCER TRIKATU ON PHARMACOKINETICS OF CEFQUINOME AND SAFETY OF SIMULTANEOUS ADMINISTRATION OF CEFQUINOME AND TOLFENAMIC ACID IN PATANWADI SHEEPen_US
dc.subVeterinary Pharmacologyen_US
dc.subjectveterinary science, pharmacologyen_US
dc.subjectstudyen_US
dc.themeEFFECT OF TOLFENAMIC ACID AND BIOENHANCER TRIKATUen_US
dc.these.typeM.Scen_US
dc.titleSTUDIES ON EFFECT OF TOLFENAMIC ACID AND BIOENHANCER TRIKATU ON PHARMACOKINETICS OF CEFQUINOME AND SAFETY OF SIMULTANEOUS ADMINISTRATION OF CEFQUINOME AND TOLFENAMIC ACID IN PATANWADI SHEEPen_US
dc.typeThesisen_US
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