A computational approach to use the active principles in Custard apple (Annona squamosa), as an ectoparasiticide by using potential target Acetylcholinesterase of Rhipicephalus sanguineus (Brown dog tick)

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dc.contributor.authorPavithra, S.
dc.contributor.authorPreetha, S.P.
dc.contributor.authorSujatha, P.L.
dc.contributor.authorSrinivasan, M.R.
dc.contributor.authorKarthikeyan, A.
dc.contributor.authorBalachandran, C.
dc.contributor.authorVenkateswaran, K.V.
dc.contributor.authorKumarasamy, P.
dc.contributor.authorTANUVAS
dc.date.accessioned2019-07-16T11:58:17Z
dc.date.available2019-07-16T11:58:17Z
dc.date.issued2016
dc.descriptionTNV_AEEICB16_2016_1-3en_US
dc.description.abstractRhipicephalus sanguineus is a brown dog tick that transmits rickettsial infection between dogs and man. It can be prevented by using ectoparasiticides generally acting through acetylcholinesterase inhibiting mechanism which is responsible for the catalysis of acetylcholine neurotransmitter. To overcome the toxic effects produced by synthetic ectoparasticides, new in silico approaches were carried out using the active principles from the custard apple. Custard apple is a small tree cultivated throughout India with various medicinal properties. A novel docking study was performed using the active ingredients present in the leaves of the custard apple. The dock scores were analysed and the best active ingredient-target interactions were identified. The active principle Norcorydine gives good docking scores with Acetylcholinesterase. Hence the present study projects the positive role of custard apple in the synthesis of bio-insecticides for the control of ectoparasites.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810114959
dc.keywordsVeterinary Science, Bioinformatics, Acetylcholinesterase, Custard apple, Norcorydine, Rhipicephalus sanguineusen_US
dc.language.isoen_USen_US
dc.pages1-3en_US
dc.subjectVeterinary Scienceen_US
dc.subjectBioinformaticsen_US
dc.titleA computational approach to use the active principles in Custard apple (Annona squamosa), as an ectoparasiticide by using potential target Acetylcholinesterase of Rhipicephalus sanguineus (Brown dog tick)en_US
dc.typeArticleen_US
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