A computational approach to use the active principles in Custard apple (Annona squamosa), as an ectoparasiticide by using potential target Acetylcholinesterase of Rhipicephalus sanguineus (Brown dog tick)
Loading...
Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Rhipicephalus sanguineus is a brown dog tick that
transmits rickettsial infection between dogs and man. It can be
prevented by using ectoparasiticides generally acting through
acetylcholinesterase inhibiting mechanism which is responsible
for the catalysis of acetylcholine neurotransmitter. To overcome
the toxic effects produced by synthetic ectoparasticides, new in
silico approaches were carried out using the active principles
from the custard apple. Custard apple is a small tree cultivated
throughout India with various medicinal properties. A novel
docking study was performed using the active ingredients present
in the leaves of the custard apple. The dock scores were analysed
and the best active ingredient-target interactions were identified.
The active principle Norcorydine gives good docking scores with
Acetylcholinesterase. Hence the present study projects the
positive role of custard apple in the synthesis of bio-insecticides
for the control of ectoparasites.
Description
TNV_AEEICB16_2016_1-3
Keywords
Veterinary Science, Bioinformatics