DIAGNOSIS AND THERAPEUTIC MANAGEMENT OF TRYPANOSOMIASIS IN DONKEYS
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Date
2022
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KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR-585226
Abstract
In the present study was conducted on trypanosomiasis in donkeys of Bidar
district, where 253 donkeys were screened for trypanosomiasis. A total of 17 donkeys
were found to be positive for trypanosomiasis. The overall incidence of
trypanosomiasis in the present study was 6.71 per cent (17/253) in donkeys. The agewise
incidence was higher (18.60 %) in the 3-6 years age group. The month-wise
incidence of trypanosomiasis in donkeys was higher in October (15.49 %). The sexwise
incidence of trypanosomiasis of donkeys was more in males. Trypanosomiasis in
donkeys showed clinical signs were unthriftiness, progressive weight loss, pale CMM,
fever, swollen prescapular lymph nodes, corneal opacity and scrotal oedema. Clinical
parameter Viz., RT, HR, RR and CLT were increased and paler CMM in
trypanosomiasis of donkeys. The haemotological analysis revealed leukopenia
neutropenia, lymphocytosis, anaemia, thrombocytopenia and biochemical analysis
revealed hypoglycemia, hypoproteinemia, hypoalbuminemia, and significant (p <0.05)
increase of A: G ratio, ALP, AST and ALT level in trypanosomiasis of donkeys. The
diagnostic efficacy of various methods among these mHCT (82.35%) and PCR
(100.00%) revealed high sensitivity and specificity. The gene sequencing and
phylogenetic analysis revealed cattle like T. evansi infection in donkeys with nucleotide
homology of cattle isolate (98.19 %) in India. The therapeutic efficacy of
isometamidium and quinapyramine prosalt were both equally effective. Isometamidium
chloride Hcl and quinapyramine sulphate and chloride both yielded successful
therapeutic results in donkeys.