PHARMACOKINETIC STUDIES OF ENROFLOXACIN AND ITS INTERACTION WITH MELOXICAM IN TURKEYS
| dc.contributor.advisor | Roy, B. K. | |
| dc.contributor.author | Toppo, Reetu | |
| dc.date.accessioned | 2017-07-31T06:38:28Z | |
| dc.date.available | 2017-07-31T06:38:28Z | |
| dc.date.issued | 2010 | |
| dc.description | PHARMACOKINETIC STUDIES OF ENROFLOXACIN AND ITS INTERACTION WITH MELOXICAM IN TURKEYS | en_US |
| dc.description.abstract | The present experiment was conducted in eighteen turkeys. The estimation of Enrofloxacin and meloxicam concentration in plasma sample was done by HPLC coupled with variable wavelength UV/VIS detector attached with an integrator and LichroCART cartridge column was used. Injection of sample and standard were done by 25 μl loop of Hamilton syringe. (i) Enrofloxacin: Mobile phase: As mentioned above. λ value: 280 nm Flow rate: 1 ml/min Temperature of oven: 40ºC (ii) Meloxicam: Mobile phase: As mentioned above. λ value: 355 nm Flow rate: 0.8 ml/min Temperature of oven: 35ºC Enrofloxacin (ENR) The mean C°p of ENR alone in turkeys ( 10.38±0.43 μg/ml) was found to be similar to ENR after concurrent administration of MLX (9.35±0.62 μg/ml) i.v. in turkeys. The mean β value of ENR alone in turkeys (0.26±0.01 h-1) was found to be similar to that of ENR after concurrent administration of MLX (0.26±0.01 h- 1) i.v. in turkeys. The mean t½β of ENR alone in turkeys (2.73±0.12 h) was found to be similar that of ENR after concurrent administration of MLX (2.70±0.13 h) i.v. in turkeys. The mean AUC of ENR alone in turkeys (20.51±1.47 mg/L.h) was found to be similar to that of ENR after concurrent administration of MLX (17.72±1.40 mg/L.h) i.v. in turkeys. The mean AUMC of ENR alone in turkeys (76.56±8.99 mg/L.h) was found to be similar to that ENR after concurrent administration of MLX (66.94±7.16 mg/L.h) i.v. in turkeys. The mean MRT of ENR alone in turkeys (3.65±0.21 h) was found to be similar to that of ENR after concurrent administration of MLX (3.73±0.18 h) i.v. in turkeys. The mean ClB of ENR alone in turkeys (8.41±0.66 ml/kg/min) was found to be similar to that of ENR after concurrent administration of MLX (9.79±0.84 ml/kg/min) in turkeys. The mean Vdarea of ENR alone in turkeys (1.95±0.08 L/kg) was found to be similar to that of ENR after concurrent administration of MLX (2.26±0.15 L/kg) in turkeys. The mean K12 of ENR in turkeys (0.84±0.12 h-1) was found to be similar to that of ENR after concurrent administration of MLX (1.22±0.26 h-1) in turkeys. The mean K21 of ENR in turkeys (1.15 ±0.08 h-1) was found to be similar to that of ENR after concurrent administration of MLX (1.51±0.23 h-1) in turkeys. The mean K2 of ENR in turkeys (0.48±0.03 h-1) was found to be similar to that of ENR after concurrent administration of MLX (0.50±0.02 h-1) in turkeys. The mean T/P ratio in turkeys (0.91±0.06) was found to be similar to that of ENR after concurrent administration of MLX (0.94±0.06) in turkeys. | en_US |
| dc.identifier.uri | http://krishikosh.egranth.ac.in/handle/1/5810026714 | |
| dc.keywords | PHARMACOKINETIC STUDIES OF ENROFLOXACIN AND ITS INTERACTION WITH MELOXICAM IN TURKEYS | en_US |
| dc.language.iso | en_US | en_US |
| dc.pages | 72 | en_US |
| dc.publisher | Birsa Agricultural University, Kanke, Ranchi, Jharkhand | en_US |
| dc.sub | Veterinary Pharmacology and Toxicology | en_US |
| dc.subject | null | en_US |
| dc.theme | PHARMACOKINETIC STUDIES OF ENROFLOXACIN AND ITS INTERACTION WITH MELOXICAM IN TURKEYS | en_US |
| dc.these.type | M.V.Sc. | en_US |
| dc.title | PHARMACOKINETIC STUDIES OF ENROFLOXACIN AND ITS INTERACTION WITH MELOXICAM IN TURKEYS | en_US |
| dc.type | Thesis | en_US |