PHARMACOKINETIC STUDIES OF ENROFLOXACIN AND ITS INTERACTION WITH MELOXICAM IN TURKEYS
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Date
2010
Authors
Journal Title
Journal ISSN
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Publisher
Birsa Agricultural University, Kanke, Ranchi, Jharkhand
Abstract
The present experiment was conducted in eighteen turkeys. The estimation of
Enrofloxacin and meloxicam concentration in plasma sample was done by HPLC coupled with
variable wavelength UV/VIS detector attached with an integrator and LichroCART
cartridge column was used. Injection of sample and standard were done by 25 μl loop of
Hamilton syringe.
(i) Enrofloxacin:
Mobile phase: As mentioned above.
λ value: 280 nm
Flow rate: 1 ml/min
Temperature of oven: 40ºC
(ii) Meloxicam:
Mobile phase: As mentioned above.
λ value: 355 nm
Flow rate: 0.8 ml/min
Temperature of oven: 35ºC
Enrofloxacin (ENR)
The mean C°p of ENR alone in turkeys ( 10.38±0.43 μg/ml) was found to
be similar to ENR after concurrent administration of MLX (9.35±0.62
μg/ml) i.v. in turkeys.
The mean β value of ENR alone in turkeys (0.26±0.01 h-1) was found to be
similar to that of ENR after concurrent administration of MLX (0.26±0.01 h-
1) i.v. in turkeys.
The mean t½β of ENR alone in turkeys (2.73±0.12 h) was found to be
similar that of ENR after concurrent administration of MLX (2.70±0.13 h)
i.v. in turkeys.
The mean AUC of ENR alone in turkeys (20.51±1.47 mg/L.h) was found to
be similar to that of ENR after concurrent administration of MLX
(17.72±1.40 mg/L.h) i.v. in turkeys.
The mean AUMC of ENR alone in turkeys (76.56±8.99 mg/L.h) was found
to be similar to that ENR after concurrent administration of MLX
(66.94±7.16 mg/L.h) i.v. in turkeys.
The mean MRT of ENR alone in turkeys (3.65±0.21 h) was found to be
similar to that of ENR after concurrent administration of MLX (3.73±0.18 h)
i.v. in turkeys.
The mean ClB of ENR alone in turkeys (8.41±0.66 ml/kg/min) was found to
be similar to that of ENR after concurrent administration of MLX
(9.79±0.84 ml/kg/min) in turkeys.
The mean Vdarea of ENR alone in turkeys (1.95±0.08 L/kg) was found to
be similar to that of ENR after concurrent administration of MLX
(2.26±0.15 L/kg) in turkeys.
The mean K12 of ENR in turkeys (0.84±0.12 h-1) was found to be similar to
that of ENR after concurrent administration of MLX (1.22±0.26 h-1) in
turkeys.
The mean K21 of ENR in turkeys (1.15 ±0.08 h-1) was found to be similar to
that of ENR after concurrent administration of MLX (1.51±0.23 h-1) in
turkeys.
The mean K2 of ENR in turkeys (0.48±0.03 h-1) was found to be similar to
that of ENR after concurrent administration of MLX (0.50±0.02 h-1) in
turkeys.
The mean T/P ratio in turkeys (0.91±0.06) was found to be similar to that
of ENR after concurrent administration of MLX (0.94±0.06) in turkeys.
Description
PHARMACOKINETIC STUDIES OF ENROFLOXACIN AND ITS INTERACTION WITH MELOXICAM IN TURKEYS
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