Pathological Evaluation of Anti-tumour Effects of Withaferin A against Experimentally Induced Mammary Tumour in Rats
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Date
2020-08
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Abstract
With the aim to explore the anti-tumour effect of Withaferin A in DMBA (7,12-
dimethylbenz[a]anthracene) induced mammary tumour in rats, seventy two female
Sprague-Dawley rats were equally distributed to control, DMBA, tamoxifen and
Withaferin A groups. Tamoxifen, which is widely used as first-line drug in the
treatment of estrogen positive breast cancer was taken as standard for comparison.
The study was conducted for a period of 16 weeks. DMBA (5 mg/rat/week/per os)
at 4 weekly doses were used for tumour induction. Piloerection was noticed after
DMBA administration. Tumour latency, location, incidence, frequency, size,
volume and weight were recorded. Hundred per cent tumour formation in DMBA
alone administered animal was observed. No metastasis was recorded. Abdominal
glands were most frequently affected in all DMBA administered groups.
Withaferin A group showed 17% tumour inhibition and the number of tumours
were almost equal to that of DMBA group. Higher incidence of carcinomas (65%)
and lower incidence of benign (35%) mammary tumours were observed in
Withaferin A group with maximum tumour frequency of seven tumours/rat when
compared with tamoxifen group. Hence further investigations are required.
Description
TNV_IJCMAS_2020_9(8)125-134
Keywords
Veterinary Science