Pathological Evaluation of Anti-tumour Effects of Withaferin A against Experimentally Induced Mammary Tumour in Rats

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dc.contributor.authorPratheepa, K
dc.contributor.authorBalachandran, C
dc.contributor.authorSridhar, R
dc.contributor.authorTANUVAS
dc.date.accessioned2020-09-04T05:37:00Z
dc.date.available2020-09-04T05:37:00Z
dc.date.issued2020-08
dc.descriptionTNV_IJCMAS_2020_9(8)125-134en_US
dc.description.abstractWith the aim to explore the anti-tumour effect of Withaferin A in DMBA (7,12- dimethylbenz[a]anthracene) induced mammary tumour in rats, seventy two female Sprague-Dawley rats were equally distributed to control, DMBA, tamoxifen and Withaferin A groups. Tamoxifen, which is widely used as first-line drug in the treatment of estrogen positive breast cancer was taken as standard for comparison. The study was conducted for a period of 16 weeks. DMBA (5 mg/rat/week/per os) at 4 weekly doses were used for tumour induction. Piloerection was noticed after DMBA administration. Tumour latency, location, incidence, frequency, size, volume and weight were recorded. Hundred per cent tumour formation in DMBA alone administered animal was observed. No metastasis was recorded. Abdominal glands were most frequently affected in all DMBA administered groups. Withaferin A group showed 17% tumour inhibition and the number of tumours were almost equal to that of DMBA group. Higher incidence of carcinomas (65%) and lower incidence of benign (35%) mammary tumours were observed in Withaferin A group with maximum tumour frequency of seven tumours/rat when compared with tamoxifen group. Hence further investigations are required.en_US
dc.identifier.urihttps://krishikosh.egranth.ac.in/handle/123456789/5810150796
dc.keywordsDMBA, Mammary tumours, Pathology, Rats, Tamoxifen, Withaferin Aen_US
dc.language.isoenen_US
dc.pages125-134en_US
dc.relation.ispartofseries;8
dc.subjectVeterinary Scienceen_US
dc.titlePathological Evaluation of Anti-tumour Effects of Withaferin A against Experimentally Induced Mammary Tumour in Ratsen_US
dc.title.alternativeInternational Journal of Current Microbiology and Applied Sciencesen_US
dc.typeArticleen_US
dc.volume9en_US
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