EVALUATION OF SONOPHORESIS MEDIATED TRANSDERMAL EFFICACY OF POLYHERBAL GEL IN BOVINE SUBCLINICAL MASTITIS
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Date
2024-01-18
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U.P. Pandit Deen Dayal Upadhyaya pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan (DUVASU) Mathura Uttar Pradesh India-281001
Abstract
The prevalence of subclinical mastitis in indigenous cows in the Brij region of Mathura was found to be 55.83%. Organized farms had a lower prevalence of 44.12%, while unorganized farms had a notably higher prevalence of 71.15%, due to factors like nutritional imbalance, poor hygiene, and lack of awareness. The 3-5 parity group had the highest prevalence at 63.7%, possibly due to structural changes in udder tissue and immune function in older cows. Sahiwal cows had a higher prevalence of 61% compared to Haryana cows at 49%, attributed to their higher milk production and udder characteristics. Diagnostic tests using the California Mastitis Test (CMT) and Somatic Cell Count (SCC) showed differences in prevalence rates. Staphylococcus aureus was the most dominant isolate in microbial analysis. Ethanol extracts of various plants contained common phytochemicals and exhibited antibacterial and anti-inflammatory properties. A polyherbal gel was formulated with synthetic polymer powder and DMSO as a permeation enhancer, and sonophoresis enhanced transdermal permeation. The gel formulations were evaluated for various parameters and showed potential in improving milk quality and reducing somatic cell counts. Pro-inflammatory markers like lactoferrin and haptoglobin were assessed to gauge inflammatory status, and the polyherbal gel treatment led to reduced concentrations of these markers. The findings indicate the potential of the polyherbal gel in managing subclinical mastitis and its effects on milk quality and udder health in indigenous cows.
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