EVALUATION OF SONOPHORESIS MEDIATED TRANSDERMAL EFFICACY OF POLYHERBAL GEL IN BOVINE SUBCLINICAL MASTITIS

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dc.contributor.advisorDr. Alok Kumar Chaudhary
dc.contributor.authorChoudhary, Shubhangi
dc.date.accessioned2024-05-07T16:07:05Z
dc.date.available2024-05-07T16:07:05Z
dc.date.issued2024-01-18
dc.description.abstractThe prevalence of subclinical mastitis in indigenous cows in the Brij region of Mathura was found to be 55.83%. Organized farms had a lower prevalence of 44.12%, while unorganized farms had a notably higher prevalence of 71.15%, due to factors like nutritional imbalance, poor hygiene, and lack of awareness. The 3-5 parity group had the highest prevalence at 63.7%, possibly due to structural changes in udder tissue and immune function in older cows. Sahiwal cows had a higher prevalence of 61% compared to Haryana cows at 49%, attributed to their higher milk production and udder characteristics. Diagnostic tests using the California Mastitis Test (CMT) and Somatic Cell Count (SCC) showed differences in prevalence rates. Staphylococcus aureus was the most dominant isolate in microbial analysis. Ethanol extracts of various plants contained common phytochemicals and exhibited antibacterial and anti-inflammatory properties. A polyherbal gel was formulated with synthetic polymer powder and DMSO as a permeation enhancer, and sonophoresis enhanced transdermal permeation. The gel formulations were evaluated for various parameters and showed potential in improving milk quality and reducing somatic cell counts. Pro-inflammatory markers like lactoferrin and haptoglobin were assessed to gauge inflammatory status, and the polyherbal gel treatment led to reduced concentrations of these markers. The findings indicate the potential of the polyherbal gel in managing subclinical mastitis and its effects on milk quality and udder health in indigenous cows.
dc.identifier.citationSelf, Advisor,book, report pratical etc.
dc.identifier.otherU.P. Pandit Deen Dayal Upadhyaya pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan (DUVASU) Mathura Uttar Pradesh India-281001
dc.identifier.urihttps://krishikosh.egranth.ac.in/handle/1/5810208795
dc.language.isoEnglish
dc.pages134p
dc.publisherU.P. Pandit Deen Dayal Upadhyaya pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan (DUVASU) Mathura Uttar Pradesh India-281001
dc.relation.ispartofseriesN/A; N/A
dc.research.problemBased on results of the study “Evaluation of sonophoresis mediated transdermal drug efficacy in subclinical mastitis in lactating cows” the following conclusions were made: 1) The overall prevalence of sub clinical mastitis was 55.8%, by CMT 44% and SCC 55.8% and prevalence was higher in during parity 3-5(63%) and in the both breed Sahiwal was found more susceptible for subclinical mastitis (61%) 2) Udder/Teat health indices indicated that pendulous type of udder (68%) and cylindrical type of teat (68%) have higher venerability against common pathogens. 3) Microbial analysis revealed that Staph. aureus (Gram ve+ bacteria) was the most commonly isolated pathogenic bacteria (42%) in the milk of affected cow. 4) Among all the formulated polyherbal, the formulation F3 showed better inhibitory effect on growth of pathogenic bacteria. 5) Novel formulated polyherbal gel (F3) has better efficacy against subclinical mastitis it can be consider one of the sustainable biogenic and alternative products and easier to apply at livestock holder at cow side without veterinary expertise. 6) Sonophoresis is also a novel and pain less technique that would be become a useful tool to enhance the transdermal efficacy of drug in udder. 7) Formulated polyherbal gel (F3) has significant effect on somatic cell count, pro-inflammatory markers. It can conclude that product has anti-inflammatory activities and also inhibit inflammatory chain reactions in subclinical mastitis but further evaluation will be recommended at mass level. 8) It also able to reduce the pathogenic bacterial load in milk in the groups of PHG, PHGS as compared to other groups. It indicates that product can be reduces the antibacterial uses in subclinical mastitis but further validation on mass population must be required. 9) Formulated polyherbal gel (F3) has no uneventful observations noticed after 60 days of post application on animal’s udder.
dc.subVeterinary Medicine
dc.themeEVALUATION OF SONOPHORESIS MEDIATED TRANSDERMAL EFFICACY OF POLYHERBAL GEL IN BOVINE SUBCLINICAL MASTITIS
dc.these.typeM.V.Sc.
dc.titleEVALUATION OF SONOPHORESIS MEDIATED TRANSDERMAL EFFICACY OF POLYHERBAL GEL IN BOVINE SUBCLINICAL MASTITIS
dc.typeThesis
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