STUDIES ON HEMATOBIOCHEMICAL, ULTRASONOGRAPHIC AND HISTOPATHOLOGICAL CHANGES ASSOCIATED WITH CANINE PYOMETRA
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Date
2022
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KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR- 585 401
Abstract
The study was conducted to ascertain the hemato-biochemical, ultrasonographic
and histopathological changes associated with cystic endometrial hyperplasia (CEH)-
pyometra in dogs and also to correlate uterine wall thickness with heamato-biochemical
and histopathological changes. Dogs presented to clinic at the Department of Veterinary
Gynaecology and Obstetrics were selected for the present study. Ten healthy diestrual
dogs were considered as control animals (Group I) whereas, twenty CEH- pyometra
affected dogs (Group II) selected for the study were further subdivided into Group II-A
and Group II-B based on the mean uterine wall thickness. Blood samples were collected
from all the animals before ovariohysterectomy and hemato-biochemical parameters were
determined using semi auto analyser. Uterine tissue samples collected from all the
animals after ovariohysterectomy were subjected for histopathological evaluation. In the
present study, nulliparous animals with mean age of 7.18 ± 0.54 years were mostly
affected. On transabdominal ultrasonography, an increase in the uterine wall thickness
(4.28 ± 0.32 mm) and uterine horn diameter (32.85 ± 13.75 mm) was observed in CEHpyometra
cases. Absolute leukocytosis with neutrophilia and lymphopenia were
prominent hematological changes whereas, elevation in BUN, creatinine, ALT and total
protein level along with hypoalbuminemia were significant findings in serum
biochemical profile of dogs with CEH- pyometra complex. Considerable alterations were
found in the histological architecture of uterine tissue in CEH- pyometra affected dogs
compared to control dogs. However, there was no correlation between uterine wall
thickness and hemato-biochemical profile and also histopathological changes in CEHpyometra
affected dogs in the present study.