PHARMACOLOGICAL AND TOXICOLOGICAL SCREENING OF KARANJ
Loading...
Date
1988
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Birsa Agricultural University
Abstract
1. Phytochemical tests conducted evidenced presence of alkaloid in both aqueous and ether extracts of the seeds of P. glabra whereas glycoside was found only in ether extract.
2. The presence of identifiable I.R. bands at 3060, 2960, 1460-70, 870 and 740 cm-1 has evidenced presence of -0-and OCH groups in the ether extract: A band at 1360 cm1 evidenced the presence of a secondary alcoholic/phenolic group also.
3. The humps observed in the U.V. spectra at 218, 250 and 285 no evidenced presence of phenoxymethyl group in the extracts.
4. It has been evidenced that in both the extracts methoxyfurano-flavone structure was present, which showed structural similarity with serotonin.
5. It has been analytically evidenced for the first time that a fair concentration of the active principle was present in the blood of mice after oral administration of the test extracts.
6. It has been evidenced by Infrared spectroscopy that the OCH group of the active principle was biotransformed in the mice apparently by demethylation process
Description
PHARMACOLOGICAL AND TOXICOLOGICAL SCREENING OF KARANJ