Pharmacokinetics of some chemotherapeutic agents in poultry
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Date
1981
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Birsa Agricultural University
Abstract
SUMMARY AND CONCLUSION
1. It has been observed that sulfonamides were absorbed from the G. I. tract of birds as per pH-pka relationship.
2. Evidence has been adduced that following single dose oral administration, sulfadimethoxine, sulfamethazine, spanbolets and sulfaquinoxaline showed max) at different time intervals indicating variation in their absorption rate from the G.1. tract of birds.
3. It has been observed that sulfadimethoxine showed the highest (max) followed by sulfamethasine, spanbolets and sulfequinoxaline post-single dose oral administration.
4. Evidence has been presented that sulfadimethoxine and sulfamethasine produced effective ther) for a longer duration of time indicating their therapeutic usefulness in the systemic infections in the chickens.
5. It was observed that sulfadimethoxine gave the longest by value followed by sulfamethazine, spanbolets and sulfaquinoxeling.
6. Evidence has been adduced that the total area under the blood level-time profile (AUC) obtained after multiple oral dose administration was largest for sulfadimethoxine followed by sulfamethazine, spanbolets and sulfaquinoxaline indicating their relative bioavailability.
7. It has been observed that acetylation was one of the major pathway of aulfonamide metabolism in the chicken and the rate and extent of this biotransformation varied with different sulfonamide compounds.
Description
Pharmacokinetics of some chemotherapeutic agents in poultry