STUDIES ON INDUCED DIABETES IN RATS WITH SPECIAL EMPHASIS ON COMBINED EFFICACY OF Gymnema sylvestre AND Momordica charantia EXTRACTS
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Date
2020-07
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KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR
Abstract
The present study was conducted in diabetes induced rats with special emphasis on
efficacy of combined herbal extracts. Gymnema sylvestre and Momordica charantia were
used at the dose of 200 mg/kg b.w each (100per cent) and Gymnema sylvestre + Momordica
charantia at the dose rate of 100 mg/kg b.w each (50per cent) and Glibenclamide at the
dose rate of 300 µg/kg b.w (50per cent) were administered in combination and compared
with an oral hypoglycaemic drug, Glibenclamide, for a period of 45 days. There was a
significant difference in various parameters like body weight, serum glucose, serum
cholesterol, serum triglycerides, ALT, AST, haemoglobin, RBC count, WBC count,
platelets count and antioxidant enzymes (SOD, GPx and CAT) in diabetic rats as compared
to normal control rats. The partial alleviation of diabetic effects was observed in all
combination of treatments in the present study