Prognostic markers and their discriminant score in predicting the outcome of Babesia gibsoni infection
Loading...
![Thumbnail Image](assets/images/Item.jpg)
Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Abstract
Background:We aimed to identify prognostic markers and their discriminant
score in predicting the lethal outcome of canine Babesia gibsoni.
Methods: Blood samples were collected from 108 client-owned dogs with
clinical signs commensurate with babesiosis to analyze haematological, biochemical,
haemostatic, antioxidant profile and thiobarbituric acid reactive
substance levels. Samples were screened for Babesia infection (microscopic
and molecular techniques). Babesiosis-affected dogs were classified into survivors
and non-survivors, and 30 healthy dogs were used in the control group.
Results: Haemoglobin, thrombocytes, catalase, urea, creatinine, alanine
aminotransferase (ALT), alkaline phosphatase, lactate and reticulocytes were
highly correlated to survival. Receiver operating characteristics analysis
revealed urea, ALT and lactate as specific prognostic markers for the disease.
The formula for calculation of discriminant scores (Di) for lethal outcome of
the disease was generated with cut-off score 0.141. The scoring system was
79% sensitive and 83% specific in predicting the lethal outcome of the disease.
Conclusions: A scoring system developed from the prognosticating markers
may aid in predicting the outcome of Babesia gibsoni infection on the day
of presentation itself enabling intensive care for those animals with a cut-off
score more than 0.141.
Description
TNV_VR_2021_188(5)1-9
Keywords
Veterinary Science