Prognostic markers and their discriminant score in predicting the outcome of Babesia gibsoni infection

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dc.contributor.authorKandasamy, Rajamanickam
dc.contributor.authorVenkatasubramanian, Leela
dc.contributor.authorLoganathasamy, Karuppusamy
dc.contributor.authorRavi Latha, Bhaskaran
dc.contributor.authorMani, Balagangatharathilagar
dc.contributor.authorTANUVAS
dc.date.accessioned2021-08-23T09:11:17Z
dc.date.available2021-08-23T09:11:17Z
dc.date.issued2021
dc.descriptionTNV_VR_2021_188(5)1-9en_US
dc.description.abstractAbstract Background:We aimed to identify prognostic markers and their discriminant score in predicting the lethal outcome of canine Babesia gibsoni. Methods: Blood samples were collected from 108 client-owned dogs with clinical signs commensurate with babesiosis to analyze haematological, biochemical, haemostatic, antioxidant profile and thiobarbituric acid reactive substance levels. Samples were screened for Babesia infection (microscopic and molecular techniques). Babesiosis-affected dogs were classified into survivors and non-survivors, and 30 healthy dogs were used in the control group. Results: Haemoglobin, thrombocytes, catalase, urea, creatinine, alanine aminotransferase (ALT), alkaline phosphatase, lactate and reticulocytes were highly correlated to survival. Receiver operating characteristics analysis revealed urea, ALT and lactate as specific prognostic markers for the disease. The formula for calculation of discriminant scores (Di) for lethal outcome of the disease was generated with cut-off score 0.141. The scoring system was 79% sensitive and 83% specific in predicting the lethal outcome of the disease. Conclusions: A scoring system developed from the prognosticating markers may aid in predicting the outcome of Babesia gibsoni infection on the day of presentation itself enabling intensive care for those animals with a cut-off score more than 0.141.en_US
dc.identifier.urihttps://krishikosh.egranth.ac.in/handle/1/5810174272
dc.keywordsCanine babesiosis, dogs, scoring system, survivalen_US
dc.language.isoEnglishen_US
dc.pages1-9en_US
dc.relation.ispartofseries;5
dc.subjectVeterinary Scienceen_US
dc.titlePrognostic markers and their discriminant score in predicting the outcome of Babesia gibsoni infectionen_US
dc.title.alternativeThe Veterinary Recorden_US
dc.typeArticleen_US
dc.volume188en_US
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