CLINICAL EFFICACY OF MIFEPRISTONE AND MISOPROSTOL IN INDUCTION OF PARTURITION IN FEMALE DOGS WITH SINGLE PUPPY SYNDROME
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Date
2018-02
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KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR- 585 401
Abstract
A clinical study was designed to evaluate the efficacy of mifepristone and
misoprostol in induction of parturition in dogs with single puppy syndrome. The
incidence of single puppy syndrome was 5.08 per cent, recorded in nine different breeds
of dogs. The highest incidence was observed in Pug while the lowest in Dachshund and
Chihuahua. Further, higher incidence was noticed in primiparous bitches with less than
two years of age. The incidence of dystocia due to single puppy syndrome was 25 per
cent. The blood glucose, serum calcium and phosphorus concentrations were within
normal physiological range in both control and treatment groups. In control group, all the
animals bearing singleton were presented with dystocia and assisted whelping was
performed. All the animals in treatment group hadn’t shown any signs of parturition even
after 62 days of gestation were administered mifepristone @ 5 mg/kg BW per orally
twice a day at 12 hours interval followed by intra vaginal administration of misoprostol
@ 200 µg for bitches with ≤ 20 kg BW and 400 µg for bitches with > 20 kg BW, 12
hours after second dose of mifepristone. The mean time taken for the expulsion of the
single pup from the time of initiation of treatment was 28 ± 2.74 hours and the mean time
taken for the expulsion of the single pup after administering misoprostol intravaginally
was 5.3 ± 1.7 hours. Live singletons were whelped in all treatment group animals giving
100 per cent results. It is concluded that the use of mifepristone and misoprostol
combination is safe and effective for induction of parturition in female dogs with single
puppy syndrome