COMPARATIVE EVALUATION OF XYLAZINE – KETAMINE AND DEXMEDETOMIDINE - KETAMINE BOLUS INDUCTION COMBINATION UNDER ISOFLURANE ANAESTHESIA IN CANINES UNDERGOING VARIOUS SURGERIES
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Date
2019-08
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KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR
Abstract
The study was conducted to evaluate xylazine – ketamine and dexmedetomidine –
ketamine bolus induction intravenously and maintenance by isoflurane anaesthesia in dogs
for various surgeries. The study was conducted in 12 clinical cases presented to VCC,
Bidar. Twelve animals were randomly divided into two groups viz., Group-I and group-II
consisting of six animals in each group. All the animals in two groups were atropinised at
the rate of 0.045mg/kg via., intramuscularly. Group-I animals received xylazine – ketamine
bolus (1 mg/kg and 10 mg/kg respectively) intravenously, in the Group-II animals
dexmedetomidine – ketamine (10 µg/kg and 10 mg/kg respectively) was administered
intravenously, after dogs reaching surgical plane of anaesthesia endotracheal intubation
was done for isoflurane (1-2 %) anaesthesia as a maintenance administration in all the
animals of two groups. Anaesthetic combinations were compared by clinicophysiological,
haemodynamic and hematobiochemical observations. Group II dogs showed quicker and
smooth induction time and prolonged recovery than group I. Degree of analgesia and
muscle relaxation were greater in group I than group II. Physiological parameters like rectal
temperature showed no significant variation in two groups. Respiratory rate and heart rate
had significant difference in two groups which was transitory in nature, hence two
combinations were well tolerated by the dogs. Haemodynamic observations had varied
significantly in two groups. Haematological observations revealed that slight changes were
observed in two groups of dogs. Biochemical parameters were varied significantly in two
groups. Hence, xylazine – ketamine bolus and dexmedetomidine – ketamine bolus
combination provides cardiac, thoracic and abdominal relaxation, there by kept the animal
in good surgical plane of anaesthesia. However, good analgesia and excellent muscle
relaxation were observed in xylazine-ketamine bolus induction and isoflurane maintenance
anaesthesia in dogs