COMPARATIVE EVALUATION OF INDUCTION COMBINATIONS ROMIFIDINE-GUAIFENESIN KETAMINE AND DEXMEDETOMIDINE GUAIFENESIN-KETAMINE UNDER ISOFLURANE ANESTHESIA IN CATTLE
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Date
2019-08
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KARNATAKA VETERINARY ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR
Abstract
The study was carried out to evaluate the feasibility of romifidine and
dexmedetomidine sedation for guaifenesin, ketamine-isoflurane general anaesthesia for
various surgeries in cattle. The study was carried out in 12 clinical cases of cattle presented
to Veterinary Clinical Complex, Veterinary College Bidar for various surgical procedures.
The cases were randomly divided into two groups consisting of six cattle in each group.
The animals of group I were administered with romifidine (10 µg/kg, IV). The animals of
group II were administered with dexmedetomidine hydrochloride (2.5µg/kg, IV)
immediately followed by guaifenesin (50 mg/kg, 5% sol). After ten minutes, the
anaesthesia was induced by administering ketamine hydrochloride (3 mg/kg, I/V) and
maintained with isoflurane (1-2%) in both the groups. Though the induction and recovery
were smooth and uneventful in both groups, faster onset of sedation, faster down time to
sternal recumbency, early recovery time to regain sternal position and to assume standing
position were noticed in cattle premedicated with romifidine than in cattle premedicated
with dexmedetomidine for guaifenesin-ketamine-isoflurane general anaesthesia.
Physiological and hemodynamic parameters like heart rate, respiratory rate, rectal
temperature, mean arterial pressure and hemoglobin oxygen saturation were fluctuated
within normal limit. Respiratory depression and bradycardia were more severe in cattle
premedicated with romifidine when compared to cattle premedicated with
dexmedetomidine. Haemoglobin, packed cell volume, total erythrocyte count and total
leukocyte count decreased significantly at maximum depth of anaesthesia in both the
groups. Neutrophilia and relative lymphocytopenia was recorded in both the groups.
Biochemical parameters decreased significantly towards the end of anaesthetic period in
both the groups, however, it was within normal physiological limits. In present study
romifidine-guaifenesin-ketamine-isoflurane combination was ideal to perform major
surgeries in cattle without any complications. However, dexmedetomidine hydrochloride
as a premedication for guaifenesin-ketamine-isoflurane anaesthetic combination was less
optimum at this given dose in cattle