PHARMACOLOGICAL AND TOXICOLOGICAL STUDIES OF VITEX NEGUNDO IN RATS
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Date
2017-08
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KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR
Abstract
The present study was conducted to evaluate various pharmacological and
toxicological properties of the Vitex negundo extract. Phytochemical analysis revealed
the presence of carbohydrates, glycosides, flavonoids, phenolics, tannins, Phytosterols,
triterpenoids. Acute oral and sub-acute toxicity studies of methanol extract was carried
out in Wistar albino rats as per the OECD guidelines 401 and 407 respectively. In acute
toxicity study, the LD50 cut off value was found to be more than 5 g/kg. No mortality and
toxicity signs were observed. In sub acute toxicity study, methanol extract was
administered @ 500, 1000, 2000 and 5000 mg/kg respectively and compared with the
control rats. The results of body weight, gross and histopathological observations of the
treated groups indicated the non toxic nature of the extract even @ 5000 mg/kg. In in
vivo anti-inflammatory study of methanol extract, in carrageenan induced rat paw edema
model, the extract @ 500 and 1000 mg/kg showed significant inhibition of rat paw edema
in dose dependent manner indicating its anti inflammatory activity.