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Birsa Agricultural University, Ranchi
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ThesisItem Open Access Pharmacological Studies of Anti hyperglycemicActivity of Some Indigenous Plants in Rabbits(Birsa Agricultural University, Ranchi, 2002) Nrip Kishore Pankaj; Dr.M.AlamHolanhena antidysenterica and Caesalpinia bonduc have shown promising antihyperglycamic effects in fasting as well as post-prandial hyperglycemic rabbits. Both test drugs in post-prandial normal rabbits produced hypoglycemia, however C. bonduc produced hypoglycemic effect in fasted as well as fed normal rabbits. These test drugs had antihypercholesterolemic effect in fasted as well as fed hyperglycemic rabbits; no such effect could be observed in normal rabbits. The seed powder of Holarrhena antidysenterica and Caesalpinia bonduc could reduce fasted as well as fed BUN / serum urea level in hyperglycemic rabbits. But this effect was not observed in normal rabbits. These indigenous drugs have no effect on hemoglobin percent. Test drugs nad no significant effect on gain or loss in the body weight, although Caesalpinia bonduc treated group had little gain in the body weight but reverse was with Holarrhena antidysenterica treated groups. Histopathological findings indicated toxic effects of Caesalpinia bonduc on vital organs like liver, kidney, and heart. Holarmena antidysenterica showed some toxic effects on liver, kidney and heart but as compared to Caesalpinia bonduc the effects were mild.ThesisItem Open Access Pharmacokinetic Studies Of Ofloxacin in Goat(Birsa Agricultural University, Ranchi, 2001) Mukti Sinha; S.N.PandayThe febrile condition decreased ofloxacin plasmalevels and duration of CPther after i.v. administration in goats. Ofloxacin may be clinically used to combat sensitive microbial infections of UT and mammary gland after oral route administration. The derived dosage regimen of ofloxacin in goats is 1 mg/kg i.v. twice daily for 3 consecutive days. 1.5 mg/kg oral for 3 consecutive days.ThesisItem Open Access Pharmacokinetics Of Enrofloxacin After Single Intravenous, Intramuscular And Subcutaneous Injection In Calves(Birsa Agricultural University, Ranchi, 2001) Vinay Kumar Singh; K.P.sinha1.The mean peak plasma concentration (28.08+1.15 μg/ml) of ENR was evidenced at 2 min declined slowly and Cpther was maintained till 10 h after single i.v. dose. (5 mg/kg) administration in calves. 2.The mean Cpmax (5.91±0.49 µg/ml) after i.m. administration was marginally higher (4.88±0.17 µg/ml) than after s.c. administration. The 'Cpmax of i.m. (15 min.) was observed lower than that of after s.c. (30 min.) administration. 3.There was delayed absorption from both the routes (i.m. and s.c.), which limited the elimination and provided a sustained release of drug from the administration site, which could be of help in extending the dosage interval. 4.The in vitro plasma protein binding of ENR ranged between 17.31 to 57.92% with an overall mean of 36.3817.57% which indicated that a major free ENR moiety was available for therapeutic effect.ThesisItem Open Access Pharmacokinetics Of Diminazene aceturate In Buffalo Calves(Birsa Agricultural University, Ranchi, 1999) Hemant Kumar Panday; B.K.Roy. The mean free CSmax (26.28±0.067 ug/ml) of DMZ was evidenced at 5 min declined slowly and CSther was maintained till 48 hr. after single i.v. dose (8mg/kg) administration in buffalo calves.. 2. It was evidenced that DMZ was rapidly absorbed after i.m. administration with a tmax at 30 min. 3. The mean peak free serum concentration (8.41±2.43 µg/ml) of DMZ was obtained at tmax of 30 min. after single i.m. dose (16mg/kg) administration. 4. The overall serum concentration of DMZ obtained after single i.m. injection was lower than its single dose i.v. administration. 5. The possible reason for attainment of lower DMZ serum concentration after i.m. administration has been explained with the help of results obtained for kinetic variables. 6. The Cumax of DMZ was observed at 1 hr. (240.00+1.77 µg/ml) and 3 hr. (286.25 +4.10µg/ml) after single dose i.v. and i.m. administration respectively. 7. Urinary excretion of DMZ was dependent on the amount of drug available in systemic circulation which indicated that this compound followed first-order elimination kinetics in buffalo calves.ThesisItem Open Access Biokinetics of Norfloxacin And Metronidazole in Goats(Birsa Agricultural University, Ranchi, 1992) Kamleshwer Jha; Dr. R.C. P. Singh.The semi logarithmic plot of blood level time profile of MNZ obtained following single dose I/V administration € 20 mg/kg b.w. in febrile goats showed a biphasic decay suggesting "two compartment open model disposition Kinetics of MNZ in goats. 2. Evidence has been presented that MNZ when given I/V au a single dose è 20 mg/kg b.w. produced Coax (50.86 ± 0.63 8/ml) and Omin (1.35 ± 0.23 ug/ml) at 2 min and 4 h respectively and Other sustained upto 4 h of drug administration. 3. The Kinetic parameters determined evidenced that the meant 1/2 & value of MNZ was 1.034 0.071 h while the sean Cl value was 8.464 + 0.384 ml/kg/min which reflected relatively a faster rate of drug elimination; the mean Cl value was 6.810 + 0.280 ml/kg/ain reflec ting the biliary excretion of MNZ. 4. The mean Vd value was found to be 0.845 ± 0.980 L/kg indicating a wide distribution of MNZ in febrile goats; the other biokinetic parameters determined were 21 (3.118 + 1.557 -1), 12 (5.103 ± 1.257 h-¹) and X₂ (1.629 + 0.104 b¹) following I/V administration of NNZ 20 mg/kg b.w.ThesisItem Open Access Biokinetics of Nalidixic Acid In Goats(Birsa Agricultural University, Ranchi, 1992) Mitrabhanu Patel; Dr. N.C. BanerjeeThe semi log-arrhythmic plot of plasma level-tine profile of Nalidixic acid in both afebrile and febrile goats showed two-compartment open model system after single dose i.. administration 10 mg/ks balle Evidence has been presented that the Cans of A after single i.v. dose (10 mg/kg) was higher in febrile goat (101.05 ± 3.25 Mg/ml) than that in normal goat (49.91 ± 0.29 pg/ml). It has been observed that the CPther of A after single dose i.v. (10 mg/kg) ranged between 5.55 ± 0.47 to101.05 3.25 ug/al. Evidence has been adduced that the other was maintained for 2.5 he end 12 hr aftor 1.v. and oral administration respectively in febrile goats. This observed Paber can even combat the infection caused by Pseudomonas app. Evidence has been presented that an appreciable amount of BA appeared in plasma of normal (3.11± 0.30 g/l) and febrile goats (4.93 0.59 g/al) at 5 min after single dose oral administration @ 50 mg/kg b.w. The reason for this has been explained on the basis of pH-pKA partition concept. It has also been observed that the neen in normal and febrile goats occurred at 1.5 hr and 1.0 hr reop actively which has been explained due to alteration in pil resulting from fever.ThesisItem Open Access Effect of Pyrogen Induced Fever on the Biokinetic of Cefazonic And Its Interaction with Probenecid in Goats(Birsa Agricultural University, Ranchi, 1991) Birendra Kumar Roy; Dr. N.C. BanerjeeIn order to achieve the objective of regulating optimization of CZ therapy in goats, a kinetic model of the drug has been constructed both in afebrile and febrile goats evincing a two compartmental open modal system'. Pharmacokinetic interaction of Probenecid with CPZ in the modulation of its kinetic behavior has also been identified. The kinetic appraisal of crz has revealed significant differences in several kinetic parameters between afebrile and febrile goats. The CPmax of CFZ in febrile goats (83.70+2.16ug/ml) was higher than in afebrile goats (67.71+1.44 ug/ml) after i.v. administration, on the contrary, after 1.m. administration the observations were reversed apparently due to concurrent differences in the values of related kinetic parameters such as Cla cla, Clu and Va Evidence has been presented that after CFZ-PB administration (1.v.) in febrile goats; the Cpax (170.00+2.33 ug/ml) of CFZ was significantly higher than that in febrile goats which received only CPZ (83.2042.16 ug/ml). Likewise, the duration of CP there was longer (3.50 h) in CPZ-PB recipient febrile goats ranging from 6.05+0.53 to 170.00 2.33 ug/ml) in contrast to other duration (45 min) ranging from 5.5040.23 to 83.20+2.16 ug/ml in febrile goats which only received CFZ. Evidence has been presented that the drug appearance time (lag) in milk of both afebrile and febrile goats after i.v. dose was 0.08 h (5 min).ThesisItem Open Access Effect Of Pyrogen Induced Fever on The Biokinetics of Ciprofloxacin In Goats(Birsa Agricultural University, Ranchi, 1991) Uttam Kumar De; Dr.K.P.Sinha1."Goat fever model was constructed with two successive administration of lipopolysaccharide (18) and toxins given at sero and 5 h which maintained fever above 0.73°c of normal body temperature upto 12 h post administration. 2. It was evident that detectable plasma concentration of CIP was observed upto 3.5 h in febrile goats and upto 3 h in normal goats following single dose i.v. administration 10 mg/kg b.. by U-V-Spectrophotometric method (model-25). 3.An overall higher moon plasma concentration of CIP in febrile goats was observed. The plasma elimination half life (t) was found to be 6.4% more than the normal goats. 4.It has been evidenced that CIP given i.v. as a single dose Ⓒ 10 mg/kg b.v. in goats maintained CPther for various infections (70.25 ug/ml) upto 3 h post drug administration in febrile goats. 5. The CIP concentration in the urine was significantly higher 5. (P/0.05) in febrile goats upto 1 h post drug administration.ThesisItem Open Access STUDIES ON THE EFFECT OF METEOROLOGICAL VARIABLES ON PHYSIOLOGICAL, HAEMATO-BIOCHEMICAL AND OXIDATIVE STRESS IN BLACK BENGAL GOAT(Birsa Agricultural University, Ranchi, 2020) Lata Murmu, Asha; Verma, R.K.Despite having well-developed mechanisms of thermoregulation, animal do not maintain strict homeothermy under extreme climatic condition (Lu, 1989).Harsh environments constitute stressful conditions to animals raised in extreme climatic areas, and as a result, animals develop various adaptive mechanisms that enable them to survive under conditions of extreme heat or extreme cold. The present investigation was therefore proposed to be undertaken with the following title and objectives: The study entitled, “The effect of Meteorological variables on Physiological, Haemato-Biochemical and Oxidative Stress in Black Bengal Goat” was conducted on twelve adult apparently healthy Black Bengal goats with the objective to determine the seasonal variations in different physiological responses, haemato-biochemical constituents and antioxidant status. Twelve Black Bengal does were investigated for their physiological, haematobiochemical and antioxidants profiles during autumn(Oct to Nov) and winter (Dec to Jan) seasons. All Physiological parameters such as rectal temperature, respiration rate and heart rate measured daily at 6 a.m. and 3 p.m. throughout the study period. Blood samples were collected from the Black Bengal goats atfortnightly interval during experimental period for various biochemical analyses. Meteorological parameters like dry bulb temperature and relative humidity were recorded daily for two times at 6 am and 3 pm for estimation of THI throughout the study period. In addition to that the meteorological data for last one year was also collected for estimation of THI. In the present study, the mean THI found during autumn and winter season was 70.45±0.60 and 57.58±0.91, respectively while the mean THI for last oneyears was 72.09±0.38 during autumn and 62.14±0.28 during winter season. During autumn season, the mean rectal temperature (0F), respiration rate (breaths/min.) and heart rate (beats/min.) were 101.17±0.19, 25.50±0.43and 69.45±1.51 respectively. During winter season, the mean rectal temperature, respiration rate and heart rate were 98.67±0.29, 22.34±0.21and 67.55±0.88, respectively. Significant (p<0.05) differences were found in between day and season (autumn and winter) for all the physiological parameters during the experimental period. These physiological parameters were directly proportional to the THI. Among the Hematological attributes, the TEC (106/μl), PCV (%), monocyte(%), neutrophil (%) and eosinophil(%)levels were found significantly (p<0.05) higher during winter than during autumn season while the non-significant results were found in Hb(g/dl), Lymphocyte (%) and Basophil(%) level in both the season. Among the biochemical constituents of black bengal goat, the mean concentration of glucose (mg/dl) were significantly (p<0.05) higher during winter than the autumn season. The serum total protein was non significantly differed. Its value decreased during winter in the present study. The serum total protein were found directly proportional to the THI and the glucose level were inversely proportional to the THI. The serum minerals studied in Black Bengal goat showed significant (p<0.05) difference in between the seasons. The serum calcium, inorganic phosphorous and magnesium levels in Black Bengal goat showed variations during both season. The serum calcium (mg/dl), inorganic phosphorous (mg/dl) and magnesium level were significantly (p<0.05) lowers during winter than autumn. The serum calcium, inorganic phosphorus and magnesium level was directly proportional to the THI. All the antioxidants that studied (SOD, LPO and GPx) showed significant (p<0.05) variations during autumn and winter season. The SOD (IU/ml), LPO (nmol of MDA/ml of packed cells) level higher during winter season than the autumn season whereas GPx(IU/ml)level was lower during winter. Thus the SOD and LPO was inversely proportional to THI and GPx was directly proportional to the THI. The study revealed that some of the parameters studied were visibly drifted from normal values as a result of climate stress during winter season. The results also highlighted drastic variations in the values of some of the constituents in animals. The information obtained is useful in understanding the adaptive physiology of the Black Bengal goats during environmental stress. The data generated may also help to distinguish and discriminate healthy animals from stressed ones under special physiological status of goats.
