Pharmacokinetics Of Enrofloxacin After Single Intravenous, Intramuscular And Subcutaneous Injection In Calves
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Date
2001
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Birsa Agricultural University, Ranchi
Abstract
1.The mean peak plasma concentration (28.08+1.15 μg/ml) of ENR was evidenced at 2 min declined slowly and Cpther was maintained till 10 h after single i.v. dose. (5 mg/kg) administration in calves.
2.The mean Cpmax (5.91±0.49 µg/ml) after i.m. administration was marginally higher (4.88±0.17 µg/ml) than after s.c. administration. The 'Cpmax of i.m. (15 min.) was observed lower than that of after s.c. (30 min.) administration.
3.There was delayed absorption from both the routes (i.m. and s.c.), which limited the elimination and provided a sustained release of drug from the administration site, which could be of help in extending the dosage interval.
4.The in vitro plasma protein binding of ENR ranged between 17.31 to 57.92% with an overall mean of 36.3817.57% which indicated that a major free ENR moiety was available for therapeutic effect.