Biokinetics of Nalidixic Acid In Goats
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Date
1992
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Birsa Agricultural University, Ranchi
Abstract
The semi log-arrhythmic plot of plasma level-tine profile of Nalidixic acid in both afebrile and febrile goats showed two-compartment open model system after single dose i.. administration 10 mg/ks balle
Evidence has been presented that the Cans of A after single i.v. dose (10 mg/kg) was higher in febrile goat (101.05 ± 3.25 Mg/ml) than that in normal goat (49.91 ± 0.29 pg/ml).
It has been observed that the CPther of A after single dose i.v. (10 mg/kg) ranged between 5.55 ± 0.47 to101.05 3.25 ug/al. Evidence has been adduced that the other was maintained for 2.5 he end 12 hr aftor 1.v. and oral administration respectively in febrile goats. This observed Paber can even combat the infection caused by Pseudomonas app.
Evidence has been presented that an appreciable amount of BA appeared in plasma of normal (3.11± 0.30 g/l) and febrile goats (4.93 0.59 g/al) at 5 min after single dose oral administration @ 50 mg/kg b.w. The reason for this has been explained on the basis of pH-pKA partition concept.
It has also been observed that the neen in normal and febrile goats occurred at 1.5 hr and 1.0 hr reop actively which has been explained due to alteration in pil resulting from fever.