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Birsa Agricultural University, Ranchi
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ThesisItem Open Access Pharmacological Studies of Anti hyperglycemicActivity of Some Indigenous Plants in Rabbits(Birsa Agricultural University, Ranchi, 2002) Nrip Kishore Pankaj; Dr.M.AlamHolanhena antidysenterica and Caesalpinia bonduc have shown promising antihyperglycamic effects in fasting as well as post-prandial hyperglycemic rabbits. Both test drugs in post-prandial normal rabbits produced hypoglycemia, however C. bonduc produced hypoglycemic effect in fasted as well as fed normal rabbits. These test drugs had antihypercholesterolemic effect in fasted as well as fed hyperglycemic rabbits; no such effect could be observed in normal rabbits. The seed powder of Holarrhena antidysenterica and Caesalpinia bonduc could reduce fasted as well as fed BUN / serum urea level in hyperglycemic rabbits. But this effect was not observed in normal rabbits. These indigenous drugs have no effect on hemoglobin percent. Test drugs nad no significant effect on gain or loss in the body weight, although Caesalpinia bonduc treated group had little gain in the body weight but reverse was with Holarrhena antidysenterica treated groups. Histopathological findings indicated toxic effects of Caesalpinia bonduc on vital organs like liver, kidney, and heart. Holarmena antidysenterica showed some toxic effects on liver, kidney and heart but as compared to Caesalpinia bonduc the effects were mild.ThesisItem Open Access Pharmacokinetic Studies Of Ofloxacin in Goat(Birsa Agricultural University, Ranchi, 2001) Mukti Sinha; S.N.PandayThe febrile condition decreased ofloxacin plasmalevels and duration of CPther after i.v. administration in goats. Ofloxacin may be clinically used to combat sensitive microbial infections of UT and mammary gland after oral route administration. The derived dosage regimen of ofloxacin in goats is 1 mg/kg i.v. twice daily for 3 consecutive days. 1.5 mg/kg oral for 3 consecutive days.ThesisItem Open Access Pharmacokinetics Of Enrofloxacin After Single Intravenous, Intramuscular And Subcutaneous Injection In Calves(Birsa Agricultural University, Ranchi, 2001) Vinay Kumar Singh; K.P.sinha1.The mean peak plasma concentration (28.08+1.15 μg/ml) of ENR was evidenced at 2 min declined slowly and Cpther was maintained till 10 h after single i.v. dose. (5 mg/kg) administration in calves. 2.The mean Cpmax (5.91±0.49 µg/ml) after i.m. administration was marginally higher (4.88±0.17 µg/ml) than after s.c. administration. The 'Cpmax of i.m. (15 min.) was observed lower than that of after s.c. (30 min.) administration. 3.There was delayed absorption from both the routes (i.m. and s.c.), which limited the elimination and provided a sustained release of drug from the administration site, which could be of help in extending the dosage interval. 4.The in vitro plasma protein binding of ENR ranged between 17.31 to 57.92% with an overall mean of 36.3817.57% which indicated that a major free ENR moiety was available for therapeutic effect.ThesisItem Open Access Pharmacokinetics Of Diminazene aceturate In Buffalo Calves(Birsa Agricultural University, Ranchi, 1999) Hemant Kumar Panday; B.K.Roy. The mean free CSmax (26.28±0.067 ug/ml) of DMZ was evidenced at 5 min declined slowly and CSther was maintained till 48 hr. after single i.v. dose (8mg/kg) administration in buffalo calves.. 2. It was evidenced that DMZ was rapidly absorbed after i.m. administration with a tmax at 30 min. 3. The mean peak free serum concentration (8.41±2.43 µg/ml) of DMZ was obtained at tmax of 30 min. after single i.m. dose (16mg/kg) administration. 4. The overall serum concentration of DMZ obtained after single i.m. injection was lower than its single dose i.v. administration. 5. The possible reason for attainment of lower DMZ serum concentration after i.m. administration has been explained with the help of results obtained for kinetic variables. 6. The Cumax of DMZ was observed at 1 hr. (240.00+1.77 µg/ml) and 3 hr. (286.25 +4.10µg/ml) after single dose i.v. and i.m. administration respectively. 7. Urinary excretion of DMZ was dependent on the amount of drug available in systemic circulation which indicated that this compound followed first-order elimination kinetics in buffalo calves.ThesisItem Open Access Biokinetics of Norfloxacin And Metronidazole in Goats(Birsa Agricultural University, Ranchi, 1992) Kamleshwer Jha; Dr. R.C. P. Singh.The semi logarithmic plot of blood level time profile of MNZ obtained following single dose I/V administration € 20 mg/kg b.w. in febrile goats showed a biphasic decay suggesting "two compartment open model disposition Kinetics of MNZ in goats. 2. Evidence has been presented that MNZ when given I/V au a single dose è 20 mg/kg b.w. produced Coax (50.86 ± 0.63 8/ml) and Omin (1.35 ± 0.23 ug/ml) at 2 min and 4 h respectively and Other sustained upto 4 h of drug administration. 3. The Kinetic parameters determined evidenced that the meant 1/2 & value of MNZ was 1.034 0.071 h while the sean Cl value was 8.464 + 0.384 ml/kg/min which reflected relatively a faster rate of drug elimination; the mean Cl value was 6.810 + 0.280 ml/kg/ain reflec ting the biliary excretion of MNZ. 4. The mean Vd value was found to be 0.845 ± 0.980 L/kg indicating a wide distribution of MNZ in febrile goats; the other biokinetic parameters determined were 21 (3.118 + 1.557 -1), 12 (5.103 ± 1.257 h-¹) and X₂ (1.629 + 0.104 b¹) following I/V administration of NNZ 20 mg/kg b.w.ThesisItem Open Access Biokinetics of Nalidixic Acid In Goats(Birsa Agricultural University, Ranchi, 1992) Mitrabhanu Patel; Dr. N.C. BanerjeeThe semi log-arrhythmic plot of plasma level-tine profile of Nalidixic acid in both afebrile and febrile goats showed two-compartment open model system after single dose i.. administration 10 mg/ks balle Evidence has been presented that the Cans of A after single i.v. dose (10 mg/kg) was higher in febrile goat (101.05 ± 3.25 Mg/ml) than that in normal goat (49.91 ± 0.29 pg/ml). It has been observed that the CPther of A after single dose i.v. (10 mg/kg) ranged between 5.55 ± 0.47 to101.05 3.25 ug/al. Evidence has been adduced that the other was maintained for 2.5 he end 12 hr aftor 1.v. and oral administration respectively in febrile goats. This observed Paber can even combat the infection caused by Pseudomonas app. Evidence has been presented that an appreciable amount of BA appeared in plasma of normal (3.11± 0.30 g/l) and febrile goats (4.93 0.59 g/al) at 5 min after single dose oral administration @ 50 mg/kg b.w. The reason for this has been explained on the basis of pH-pKA partition concept. It has also been observed that the neen in normal and febrile goats occurred at 1.5 hr and 1.0 hr reop actively which has been explained due to alteration in pil resulting from fever.ThesisItem Open Access Effect of Pyrogen Induced Fever on the Biokinetic of Cefazonic And Its Interaction with Probenecid in Goats(Birsa Agricultural University, Ranchi, 1991) Birendra Kumar Roy; Dr. N.C. BanerjeeIn order to achieve the objective of regulating optimization of CZ therapy in goats, a kinetic model of the drug has been constructed both in afebrile and febrile goats evincing a two compartmental open modal system'. Pharmacokinetic interaction of Probenecid with CPZ in the modulation of its kinetic behavior has also been identified. The kinetic appraisal of crz has revealed significant differences in several kinetic parameters between afebrile and febrile goats. The CPmax of CFZ in febrile goats (83.70+2.16ug/ml) was higher than in afebrile goats (67.71+1.44 ug/ml) after i.v. administration, on the contrary, after 1.m. administration the observations were reversed apparently due to concurrent differences in the values of related kinetic parameters such as Cla cla, Clu and Va Evidence has been presented that after CFZ-PB administration (1.v.) in febrile goats; the Cpax (170.00+2.33 ug/ml) of CFZ was significantly higher than that in febrile goats which received only CPZ (83.2042.16 ug/ml). Likewise, the duration of CP there was longer (3.50 h) in CPZ-PB recipient febrile goats ranging from 6.05+0.53 to 170.00 2.33 ug/ml) in contrast to other duration (45 min) ranging from 5.5040.23 to 83.20+2.16 ug/ml in febrile goats which only received CFZ. Evidence has been presented that the drug appearance time (lag) in milk of both afebrile and febrile goats after i.v. dose was 0.08 h (5 min).ThesisItem Open Access Effect Of Pyrogen Induced Fever on The Biokinetics of Ciprofloxacin In Goats(Birsa Agricultural University, Ranchi, 1991) Uttam Kumar De; Dr.K.P.Sinha1."Goat fever model was constructed with two successive administration of lipopolysaccharide (18) and toxins given at sero and 5 h which maintained fever above 0.73°c of normal body temperature upto 12 h post administration. 2. It was evident that detectable plasma concentration of CIP was observed upto 3.5 h in febrile goats and upto 3 h in normal goats following single dose i.v. administration 10 mg/kg b.. by U-V-Spectrophotometric method (model-25). 3.An overall higher moon plasma concentration of CIP in febrile goats was observed. The plasma elimination half life (t) was found to be 6.4% more than the normal goats. 4.It has been evidenced that CIP given i.v. as a single dose Ⓒ 10 mg/kg b.v. in goats maintained CPther for various infections (70.25 ug/ml) upto 3 h post drug administration in febrile goats. 5. The CIP concentration in the urine was significantly higher 5. (P/0.05) in febrile goats upto 1 h post drug administration.
