MODULATORY EFFECT OF LEAD ON THE AIRWAY SMOOTH MUSCLE FUNCTIONAL ACTIVITY IN THE PRESENCE OF FLAVONONE NARINGIN
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Date
2017-03
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SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA
Abstract
ABSTRACT:
Lead occurs naturally in the Earth‟s crust and is an environmental contaminant
of increasing importance. It is a highly toxic heavy metal and affects all organs and
systems of an organism causing several acute and chronic diseases. Naringin is a
flavonone glycoside obtained from tomatoes, grape fruits and many other citrus fruits. It
is a very common dietary constituent and is reported to have wide spectrum of
pharmacological actions including significant vaso-relaxant effect on smooth muscles.
In view of this, the present study is designed to know the modulatory effect of lead on
the contractile or relaxant responses of various pharmacological agents on sheep
tracheal smooth muscle in the presence of naringin in vitro. The control and lead acetate
treated tracheal smooth muscle strips were exposed to the contractile and relaxing
agents like acetylcholine, salbutamol, sildenafil and sodium nitro prusside both in the
absence and presence of naringin in cumulative doses. At the end of each study the
strips were preserved for histopathological studies. Mean EC50 value for contractile
response of acetylcholine obtained in the absence of lead acetate was 1.99 X 10-7 M and
in the presence of lead acetate it has decreased to 1.00 X 10-7 M with a significant left
shift. Mean IC50 values for relaxant responses of salbutamol, sildenafil and sodium
nitro prusside were 9.77 X 10-7 M, 1.69 X 10-6 M and 1.35 X 10-6 M respectively. In the
presence of lead acetate there was a significant increase in the mean IC50 values of
salbutamol, sildenafil and sodium nitro prusside to 2.75 X 10-5 M, 1.73 X10-5 M and
1.02 X 10-5 M respectively. In the presence of flavonone naringin, the mean IC50 values
of relaxing agents salbutamol, sildenafil and sodium nitro prusside decreased to 9.33 X
10-6 M, 8.12 X 10-6 M and 9.12 X 10-6 M respectively.
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