IMMUNE RESPONSE TO PESTE DES PETITS RUMINANTS VIRUS VACCINE IN GOATS
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Date
2020
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Abstract
A study was undertaken to assess the immune response of the commercially available peste
des petits ruminants virus (PPRV) vaccines in goats of Tamil Nadu under field conditions. Two
commercial PPRV vaccines from manufacturers A and B, available in the state were used from
2016 to 2018. The serum samples were collected from the PPRV vaccinated goats on 0, 28, 90,
180 and 365 days post vaccination (DPV) for the four groups and tested for PPRV antibodies by
competitive enzyme-linked immunosorbant assay (c-ELISA) and micro serum neutralisation test
(mSNT). Group 1 (4 months to 1 yr of age) and Gr 4 (45 days-old) goats were vaccinated with
either PPRV vaccine from vaccine manufacturer A or B; Gr 2 goats (>1 yr of age) which were
previously vaccinated once with PPRV vaccine and revaccinated with PPRV vaccine from the
same manufacturer A or B; Gr 3 goats (>1 yr of age) revaccinated with PPRV vaccine from
manufacturer A, which were previously vaccinated once with PPRV vaccine from different
manufacturer B and vice versa. In all the four groups, the mean percentage inhibition (PI) values
on c-ELISA continued to increase from 0 DPV (21.28±0.54) to 90 DPV (83.88±0.70). Thereafter
there was decline in the average PI values with the presence of PPRV antibody even at 365 DPV
(83.88±0.70 to 54.19±0.78). The study suggested that vaccine from either of the manufacturer can
be used for subsequent revaccination so as to produce rapid immune response.
Description
TNV_IJSR_2020_25(2)181-185
Keywords
Veterinary Science