IN VITRO AND IN VIVO EVALUATION OF MONTMORILLONITE TO AMELIORATE THE TOXICOLOGICAL EFFECTS OF AFLATOXIN B1 IN BROILERS
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Date
2019-01
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KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR
Abstract
A study was conducted to evaluate In vitro binding efficiency of binder
(montmorillonite) for aflatoxin B1 (AFB1) and its ameliorative effect in commercial
broiler chicken for 42 days. The binder was added to compounded broiler feed at three
levels, 0.1%, 0.2% and 0.5% and AFB1 was added at approximately 0.5 ppm level to all
the flasks. Binding ability was tested at pH 4.5 and 6.5. At pH 4.5, motmorillonite
showed higher binding (46.47 %) at 0.2% level than other other two levels of the binder.
However, no significant difference was recorded in binding per cent between different
levels of the binder at either of the pH. In the trial, broiler chicks were randomly assigned
to one of the three dietary treatments: T1 (basal diet), T2 (control + 0.5 ppm AFB1) and
T3 (control + 0.5 ppm aflatoxin + 0.2% montmorillonite). The aflatoxin challenge was
successful with depression in growth performance, elevated levels of aspartate
aminotransferase (AST) and G