EFFICACY OF DIFFERENT CEPHALOSPORINS ON RESPIRATORY DISEASE OF BACTERIAL ORIGIN IN BUFFALOES
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Date
2023
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KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR-585226
Abstract
The aim of present study was to record the clinical and haemato-biochemical
findings, to identify the bacterial causative agent, antibiogram of isolated bacteria and
efficacy of different cephlosporins in respiratory disease of bacterial origin in buffaloes.
The present study revealed that the occurrence of respiratory disease of bacterial origin in
buffaloes was 6 per cent. Graded buffaloes and buffaloes of 6-9 years aged groups were
commonly affected. The most predominant clinical signs observed in the study were
anorexia, pyrexia, respiratory distress, congested mucous membrane, nasal discharge,
depression, ocular discharge, coughing and open-mouth breathing. The most predominant
physical examination findings were tachypnoea, tachycardia, crackles, wheezes and
dyspnoea. Significant increase was recorded in parameters of rectal temperature,
respiratory rate and heart rate. Haematological examination revealed a decrease in
hemogram values, leucocytosis with neutrophilia and lymphopenia. Serum biochemical
examination revealed an increase in total protein, aspartate aminotransferase and blood
urea nitrogen followed by a decrease in albumin levels. Thoracic radiography revealed
pneumonic changes in lungs of affected buffaloes. Isolation and identification of nasal
swab samples revealed E.coli, Pasteurella spp, Staphylococcus spp, Streptococcus spp,
Klebsiella spp, Pseudomonas spp, Diplococci spp and Bacilli spp. Bacterial isolates were
found to be sensitive to ceftriaxone (66.67%). Therapeutic trial in affected buffaloes
revealed the efficacy of cefquinome was proved to be superior followed by ceftiofur in
comparison with ceftriaxone. Cefquinome along with supportive therapy was effective in
the treatment of respiratory disease of bacterial origin in buffaloes caused by multiple
bacteria.