CYTOLOGICAL, PATHOMORPHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDIES ON CANINE CUTANEOUS NEOPLASMS
| dc.contributor.advisor | SUDHA RANI CHOWDARY .CH (MAJOR) | |
| dc.contributor.advisor | SAMATHA .V | |
| dc.contributor.advisor | SRINIVASA RAO .T | |
| dc.contributor.author | SIRISHA KAVETI | |
| dc.date.accessioned | 2024-07-05T05:31:08Z | |
| dc.date.available | 2024-07-05T05:31:08Z | |
| dc.date.issued | 2023-04 | |
| dc.description.abstract | The present study was undertaken to know the occurrence of canine cutaneous neoplasms, to classify and study the gross, cytology, histopathology and AgNOR count and to evaluate different tumor markers by IHC. In the present study, 62 canine cutaneous neoplasms were histologically classified into 19 types, of which epithelial neoplasms (59.7%) had the highest occurrence followed by mesenchymal (17.7%), round cell and melanocytic neoplasms (11.3% each). The occurrence of malignant tumors (64.5%) was higher compared to benign tumors (35.5%). In the present study, dogs affected with cutaneous neoplasms ranged from 1 to 15 years of age with highest occurrence in 7 to 9 years age group. Males (71%) were more affected than females (29%). The highest occurrence of canine cutaneous neoplasms was recorded in Non - descript dogs followed by Labrador retriever and Spitz. With respect to location, the occurrence was highest in head (37.1%) followed by extremities (32.3%), trunk (19.4%) and neck (11.3%) regions. Grossly, the tumors were 1 to 10 cm in diameter, round to oval, dome, irregular and cauliflower shaped with soft to firm consistency. Cytology of benign tumors revealed uniform to mild pleomorphic cells, low nuclear to cytoplasmic ratio and condensed chromatin, while, cytology of malignant tumors revealed high cellularity, moderate to severe pleomorphism, anisocytosis, anisokaryosis, high nuclear to cytoplasmic ratio, single to multiple nuclei and nucleoli and emperipolesis. The different histologic types of canine cutaneous neoplasms recorded in the present study were papilloma (4.8%), basal cell carcinoma (12.9%), squamous cell carcinoma (4.8%), basosquamous cell carcinoma (3.2%), trichoblastoma (6.5%), sebaceous adenoma and sebaceous epithelioma (3.2% each), sebaceous carcinoma (8.1%), hepatoid gland adenoma (6.5%), hepatoid gland carcinoma and apocrine gland carcinoma (3.2% each), lipoma (3.2%), fibroma (1.6%), fibrosarcoma (8.1%), haemangiopericytoma (1.6%), haemangioma (3.2%), plasma cell tumor (3.2%), mast cell tumor (8.1%) and malignant melanoma (11.3%). Of all the histologic types, basal cell carcinoma had the highest occurrence. The proliferative cellular activity of canine cutaneous neoplasms was demonstrated by AgNOR staining. The mean AgNOR count ranged from 1.68 to 3.08 and malignant tumors had higher AgNOR count compared to benign tumors. Twenty three canine cutaneous tumors were subjected to immunostaining of different tumor markers viz. cytokeratin, vimentin, S100 and CD117. Basal cell carcinoma, squamous cell carcinoma, sebaceous carcinoma, hepatoid gland carcinoma and apocrine gland carcinoma were positive to cytokeratin, fibrosarcoma and haemangiopericytoma were positive to vimentin, mast cell tumors were positive to CD117 and malignant melanomas were positive to S100 and vimentin. The present study has provided certain insights on the occurrence of canine cutaneous neoplasms in this geographical region of Andhra Pradesh. It has also put on record the cytological, pathomorphological and immunohistochemical findings of different canine cutaneous neoplasms. | |
| dc.identifier.uri | https://krishikosh.egranth.ac.in/handle/1/5810211477 | |
| dc.language.iso | English | |
| dc.pages | 197 | |
| dc.publisher | SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA | |
| dc.sub | Veterinary Pathology | |
| dc.theme | CYTOLOGICAL, PATHOMORPHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDIES ON CANINE CUTANEOUS NEOPLASMS | |
| dc.these.type | M.V.Sc. | |
| dc.title | CYTOLOGICAL, PATHOMORPHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDIES ON CANINE CUTANEOUS NEOPLASMS | |
| dc.type | Thesis |