TRAMADOL PRE-EMPTIVE ANALGESIA FOR ROMIFIDINE-PROPOFOL AND XYLAZINE PROPOFOL INDUCTION WITH ISOFLURANE MAINTENANCE FOR SURGERIES OF DOGS
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Date
2019-08
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KARNATAKA VETERINARY ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR
Abstract
The study was conducted to evaluate romifidine and xylazine as pre-anaesthetic
for propofol-isoflurane anaesthesia in dogs for various surgeries. The study was
conducted in 12 linical cases presented to VCC, Bidar. Twelve animals were randomly
divided into two groups viz., Group-I and Group-II and consisting of six animals in each
group. All the animals of boththe groups were atropinised at the rate of 0.045mg/kg and
tramadol at the dose rate of 2 mg/kg body weight intramuscularly. Group-I animals
received romifidine (10µg/kg) intravenously, In the Group-II animals xylazine (1mg/kg)
was administered intravenously, anaesthesia was induced by administering propofol
(3mg/kg) intravenously after 10 minutes of pre-anaesthetic administration in both the
groups. Maintenance of anaesthesia was done under isoflurane in both groups.
Anaesthetic combinations were compared by clinicophysiological, haemodynamic and
haematobiochemical observations. Group I dogs showed quicker onset of sedation,
narrowly quicker induction time and slower recovery than group II dogs. Degree of
analgesia and muscle relaxation were greater in group I than group II dogs. Physiological
parameters like rectal temperature and heart rate showed no significant variation in both
groups. Respiratory rate decreased significantly in both the groups which was transitory
in nature hence three combinations were well tolerated by the dogs. Haemodynamic
observations did not vary significantly in both the groups. Haematological observations
revealed that slight changes were observed in both the groups of dogs. Biochemical
parameters did not vary significantly in both the groups, indicating that two anaesthetic
combinations did not produce any adverse effects on liver and kidney function. Hence,
Romifidine is an alternative pre-anaesthetic for xylazine for propofol - isoflurane
anaesthesia for various surgeries in dogs. However, good analgesia and excellent muscle
relaxation were observed in Romifidine-propofol-isoflurane anaesthesia in dogs