COMPARATIVE EVALUATION OF INTRADERMAL VIS-A-VIS INTRAMUSCULAR PRE-EXPOSURE PROPHYLACTIC VACCINATION AGAINST RABIES IN CATTLE
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Date
2022
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KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR
Abstract
The present study was conducted to evaluate efficacy of rabies pre-exposure prophylactic vaccine administered through different routes and to sequentially monitor level of rabies virus neutralizing antibody titres in cattle. The study was carried out in Department of Veterinary Medicine utilising 30 cattle from LFC, Veterinary College, Bengaluru. These cattle were divided into five groups of six animals each. Animals of Group I and III were immunized with 1 ml and 0.2 ml of rabies vaccine through intramuscular (IM) and intradermal (ID) route respectively, on day 0 with booster dose on day 21. Animals of Group II and IV were immunized with 1 ml and 0.2 ml of rabies vaccine through IM and ID route respectively, on day 0 alone without booster dose. Group V cattle were not vaccinated and maintained as control. Serum samples were collected on day 0, 14, 28 and 90 to estimate rabies virus neutralizing antibody (RVNA) titre by RFFIT. RVNA titres were above adequate level (≥ 0.5 IU/ml) in all cattle administered with rabies vaccine through IM and ID route by day 14 and maintained for 90 days until completion of study. The results of this study indicated that both routes of vaccination are safe and effective in providing protection against rabies. Even without booster dose, adequate level of immune response (≥ 0.5 IU/ml) was maintained for a minimum of 90 days. Hence, both routes can be considered for pre-exposure prophylaxis. However, ID route proved to be more economical due to its dose sparing effect.