STUDIES ON THE EFFECTS OF DEXMEDITOMIDINE PREMEDICATION ON KETAMINE INDUCTION AND ISOFLURANE GENERAL ANAESTHESIA IN CATTLE
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Date
2017-12-01
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KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR
Abstract
The study was conducted in cattle to standardizethedosage of dexmedetomidine as
premedicant in cattle and to study the influence of dexmeditomidine premedication on
ketamine induction and isoflurane general anaesthesia. During the present study the
following parameters were assessed: (i) physiological parameters like rectal temperature,
heart rate and respiratory rate,(ii) hematological parameters viz., total erythrocyte count
(TEC), hemoglobin concentration (Hb), packed cell volume (PCV), total leukocyte count
(TLC), differential leukocyte count (DLC),(iii)biochemical parameters like aspartate
aminotransferase (AST), blood urea nitrogen(BUN), blood glucose and creatinine, (iv)
blood gas parameters like PaO2, PaCO2 and blood pH (v) heamodynamic parameters like
electrocardiography (ECG) and blood pressure (BP) (vi) anaesthetic parameters such as
thequality of sedation, induction time, duration of anaesthesia, recovery time, extubation
time, time for sternal recumbency and time for unassisted standing were assessed during
the period of anaesthesia. Results revealed, in all the animals there were non-significant
minor alterations in physiological, hematological and biochemical parameters, whereas
some significant changes were observed in PaO2 and changes were only transient and
within normal physiological limits. In the present study dexmedetomidine caused the
smooth, effective, satisfactory and adequate sedation in three minutes of its
administration and facilitated the induction of anaesthesia with minimal changes
physiological parameters of cattle subjected for general anaesthesia. Findings were
suggestive of anaesthetic protocol employed in the study was safe and effective provided
the rapid and smooth induction along with faster recovery in all the animals during the
study without any untowardevents or the complications.