Evaluation of Anti-tumour effects of Withaferin A Using Molecular Markers in a Rat Model of Mammary Carcinogenesis

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dc.contributor.authorPratheepa, K
dc.contributor.authorVijayarani, K
dc.contributor.authorBalachandran, C
dc.contributor.authorSridhar, R
dc.contributor.authorVijay, K
dc.contributor.authorTANUVAS
dc.date.accessioned2020-09-04T06:32:58Z
dc.date.available2020-09-04T06:32:58Z
dc.date.issued2020-08
dc.descriptionTNV_IJCMAS_2020_9(8)263-272en_US
dc.description.abstractThe present study was designed to evaluate the anti-tumour potential of Withaferin A in DMBA (7,12-dimethylbenz[a]anthracene) induced rat mammary tumorigenesis. Seventy two female Sprague-Dawley rats were equally divided into control, DMBA, DMBA + tamoxifen (Standard drug) and DMBA +Withaferin A groups. DMBA (5 mg/rat/week/per os) at 4 weekly doses were used for tumour induction. Mammary tumours were collected on the 30th, 75th and 120th day after the initial dose of DMBA administration. The expression of p53, bcl-2, bax and PCNA was analysed by immunohistochemistry and RT-PCR. Oral administration of Withaferin A (16 mg/kg body weight/thrice a week/ per os) showed increased incidence of carcinomas by modulating markers of apoptosis (Bax, Bcl-2), cell survival (p53) and proliferation (PCNA) when compared to the standard drug tamoxifen (100 μg/kg body weight/day/per os).en_US
dc.identifier.urihttps://krishikosh.egranth.ac.in/handle/1/5810150802
dc.keywordsBax, Bcl2, DMBA, Immunohistochemistry, Mammary tumour, p53, PCNA, RTPCR, Tamoxifen, Withaferin Aen_US
dc.language.isoenen_US
dc.pages263-272en_US
dc.relation.ispartofseries;8
dc.subjectVeterinary Scienceen_US
dc.titleEvaluation of Anti-tumour effects of Withaferin A Using Molecular Markers in a Rat Model of Mammary Carcinogenesisen_US
dc.title.alternativeInternational Journal of Current Microbiology and Applied Sciencesen_US
dc.typeArticleen_US
dc.volume9en_US
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