Antioxidant Status in Curcumin Treated Rats in Experimental Mammary Carcinogenesis
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Date
2014-07
Journal Title
Journal ISSN
Volume Title
Publisher
Tamil Nadu Veterinary and Animal Sciences University
Abstract
The present study was carried out to evaluate the effect of curcumin
on lipid peroxidation and antioxidant levels in DMBA (7, 12 Diemthyl
Benanthracene) induced mammary carcinogenesis in rats. Twenty four
Sprague-Dawley rats were equally distributed to control, DMBA, Tamoxifen
(Standard drug) and curcumin groups. DMBA group showed significant
(P<0.05) increase in lipid peroxidation and antioxidants superoxide dismutase
(SOD) and catalase (CAT) levels besides reduced glutathione (GSH). Whereas,
curcumin and Tamoxifen treated groups did not show any significant difference
in lipid peroxidation and antioxidant status when compared to the control.
Selective growth advantage of tumour cells was evident in the DMBA group
and curcumin was able to prevent lipid peroxidation.
Description
Keywords
Antioxidant, Curcumin, DMBA, Lipid peroxidation, Mammary carcinogenesis