Protective action of curcumin and nano-curcumin against arsenic- induced genotoxicity in rats in vivo

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dc.contributor.authorSankar, Palanisamy
dc.contributor.authorTelang, Avinash Gopal
dc.contributor.authorRamya, Kalaivanan
dc.contributor.authorVijayakaran, Karunakaran
dc.contributor.authorKesavan, Manickam
dc.contributor.authorSarkar, Souvendra Nath
dc.contributor.authorTANUVAS
dc.date.accessioned2018-06-05T12:13:34Z
dc.date.available2018-06-05T12:13:34Z
dc.date.issued2014-07
dc.descriptionTNV_MBR_2014(1-10)en_US
dc.description.abstractenite (25 ppm) daily through drinking water for 42 days. Groups III, IV and V were maintained as in Group II, however, they were also administered empty nanoparticle, curcumin (100 mg/kg bw) and CUR-NP (100 mg/kg bw), respec- tively, by oral gavage during the last 14 days of arsenic exposure. On the 43rd day, genotoxic effects were evalu- ated in bone marrow cells. Arsenic increased chromosomal aberrations, micronuclei formation and DNA damage. Both free curcumin and CUR-NP attenuated these arsenic- mediated genotoxic effects. However, the result suggests that nanoformulation have better protective effect than free curcumin at the same dose level.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810049268
dc.keywordsCurcumin - Arsenic - Nano-curcumin - Genotoxicity - Ratsen_US
dc.language.isoenen_US
dc.pages1-10en_US
dc.publisherSpringeren_US
dc.subjectVeterinary Scienceen_US
dc.titleProtective action of curcumin and nano-curcumin against arsenic- induced genotoxicity in rats in vivoen_US
dc.title.alternativeMolecular Biology Reporten_US
dc.typeArticleen_US
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