Protective action of curcumin and nano-curcumin against arsenic- induced genotoxicity in rats in vivo
Loading...
Date
2014-07
Journal Title
Journal ISSN
Volume Title
Publisher
Springer
Abstract
enite
(25 ppm) daily through drinking water for 42 days. Groups
III, IV and V were maintained as in Group II, however,
they were also administered empty nanoparticle, curcumin
(100 mg/kg bw) and CUR-NP (100 mg/kg bw), respec-
tively, by oral gavage during the last 14 days of arsenic
exposure. On the 43rd day, genotoxic effects were evalu-
ated in bone marrow cells. Arsenic increased chromosomal
aberrations, micronuclei formation and DNA damage. Both
free curcumin and CUR-NP attenuated these arsenic-
mediated genotoxic effects. However, the result suggests
that nanoformulation have better protective effect than free
curcumin at the same dose level.
Description
TNV_MBR_2014(1-10)
Keywords
Veterinary Science