MOLECULAR EPIDEMIOLOGY OF FOOT AND MOUTH DISEASE VIRUS ISOLATES FROM ANDHRA PRADESH
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Date
2007-03
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SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA
Abstract
ABSTRACT:
Hither to the prophylactic vaccinations were being employed to protect
the livestock from devastating FMD. Even then the occurrence of outbreaks
were recorded. Hence, it has triggered the idea in the minds of the scientists to
study the divergency of antigenicity of FMDV isolates which could be
incorporated in the vaccination programmes. Hence, a modest attempt has
been made on exposition of various dimensions of molecular epidemiology its
applications and implications in disease management to evolve a suitable
vaccine strain to cater the needs of farmers lest the occurrence will continue.
The disease was recorded round the year from different agro-climatic
zones of Andhra Pradesh, both among vaccinates and unvaccinated animals
with maximum incidences in cattle species (1 7.45%) with type 0.
The complementation of results of antigenic detection in clinical
samples showed virus isolation as golden standard while RT-PCR as sensitive
and specific where as ELISA as dependable diagnostic tool.
The FMDV field isolates of diffment ago-climatic zones of Andhra
Pradesh were catalogued and master banks were prepared.
In FMDV detection of OP fluids from carrier animals more percentage
of positives were recorded by RT-PCR technique (47.8%).
The phylogenetic analysis of type 0 and A isolates, revealed circulation
of genetically heterologus genotypes that might have antigenically drifted away
from current vaccine strains in vogue. It has been extrapolated the genetic
variancy of deduced amino acid sequences to understand the heterogenicity in
antigenecity. The isolates recovered corroborated serological relatedness to
vaccine strains OIND R2/75 and AIND 17/82
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