EVALUATION OF CERTAIN PARAMETERS FOR DETECTION OF HEPATIC DISORDERS IN DOGS
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Date
2022
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KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR
Abstract
The present study was conducted at Veterinary College Hospital, Hebbal, Bengaluru to study the haemato-biochemical changes and to assess the efficacy of alpha GST in the diagnosis of hepatic disorders in dogs. Ten apparently healthy dogs (control group) and 20 dogs with clinical signs suggestive of hepatic disorders were selected for the present study. All the animals were subjected to detailed clinical examination, haemato-biochemical analysis, α GST estimation and ultrasonography. The clinical signs exhibited by dogs with hepatic disorders were partial/complete anorexia, lethargy, ascites, vomiting, fever, polydipsia, polyuria, icterus, weight loss, diarrhoea, limb oedema and melena. The major haematological changes observed were reduced Hb concentration, TEC, PCV, platelet count and increased TLC in dogs with hepatic disorders compared to control group. The major biochemical changes recorded were increased ALT, GGT, Total bilirubin and decreased Total Protein and Albumin. There was a significant elevation in α GST levels in dogs with hepatic disorders compared to control group. Among the dogs confirmed for hepatic disorders, twelve dogs were selected and divided into Group I and Group II, each consisting of six dogs. Group I dogs were treated with Silybin and S-adenosyl methionine and Group II dogs with herbal preparations containing Chicory (Kasani) and Caper Bush for 15 days along with symptomatic therapy. Though both the therapeutic regimens were efficacious in treating hepatic disorders in dogs, Silybin and S-adenosyl methionine was found to be more efficacious due to faster clinical recovery and lesser time for the restoration of haemato-biochemical parameters to near normalcy