BIOENHANCING EFFECT OF BERBERIS ARISTATA AND CURCUMA LONGA ON PHARMACOKINETICS OF AMOXICILLIN IN CALVES

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dc.contributor.advisorVarshneya, C.
dc.contributor.authorTandon, Tamanna
dc.date.accessioned2019-02-04T05:50:02Z
dc.date.available2019-02-04T05:50:02Z
dc.date.issued2014-07
dc.description.abstractThe bioenhancing effects of Berberis aristata and Curcuma longa (30 mg.kg-1) were studied on pharmacokinetics of amoxicillin in calves. The studies were carried out on six apparently healthy male calves (2-3 months of age). The calves were divided into six groups and amoxicillin was administered at the dose rate of 10 mg.kg-1 by intravenous and oral route in groups I and II, respectively. The animals of group III and IV received extracts of Berberis aristata and Curcuma longa along with amoxicillin, respectively. The animals of group V and VI received only the extracts of Berberis aristata and Curcuma longa, respectively. The blood samples were collected at 2.5 min., 5 min., 10 min., 15 min., 30 min., 1h, 2 h, 4 h, 6 h, 8 h, 10 h and 12 h following the intravenous administration and samples were collected at 15 min., 30 min., 1h, 2 h, 3 h, 4 h, 5 h, 6 h, 8 h, 10 h and 12 h after oral administration. The samples were analysed for amoxicillin using agar plate diffusion method. The disposition kinetics of amoxicillin followed two compartment open model following intravenous and oral administration. Following a single intravenous injection of amoxicillin, the plasma level was 11.9 ± 0.21 μg.ml-1 at 2.5 min. and the drug was detected above MIC in plasma upto 6 h. The pharmacokinetic parameters of the distribution and elimination phase of amoxicillin revealed rapid distribution of the drug into body fluids and tissues with a short distribution half life of 0.13 ± 0.01 h. A fair distribution of drug was also reflected by the high values of K12/K21 ratio (1.81 ± 0.05) and AUC (16.13 ± 0.28 μg.ml-1.h). The values of t1/2β, Kel, ClB and MRT were: 2.50 ± 0.07 h, 0.88 ± 0.01h-1, 620.75 ± 10.49 ml.kg-1.h-1 and 3.18 ± 0.08 h, respectively. After oral administration the peak plasma level was achieved at 3 h and the values of AUC, t1/2β, ClB and MRT were: 9.25 ± 0.31 μg.ml-1.h, 1.66 ± 0.05 h, 617.03 ± 10.71 ml.kg-1.h-1 and 3.79 ± 0.06 h, respectively. The simultaneous administration of extracts of Berberis aristata and Curcuma longa altered both the absorption and elimination phases. The findings of the present study revealed that amoxicillin has a bioavailability of 57 percent. The simultaneous administration of extracts significantly (P<0.05) increased the oral bioavailability of amoxicillin.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810093450
dc.keywordsCurcuma longaen_US
dc.language.isoenen_US
dc.pages71en_US
dc.publisherCSKHPKV, Palampuren_US
dc.subVeterinary Pharmacology and Toxicologyen_US
dc.subjectnullen_US
dc.themeBioenhancing effect of Berberis aristata and Curcuma longaen_US
dc.these.typeM.V.Sc.en_US
dc.titleBIOENHANCING EFFECT OF BERBERIS ARISTATA AND CURCUMA LONGA ON PHARMACOKINETICS OF AMOXICILLIN IN CALVESen_US
dc.typeThesisen_US
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